Alcoholism: Emotion and Thinking
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Purpose
The purpose of this study is to determine whether long-term chronic alcoholism is associated with changes in emotional functioning and brain structure and function.
| Condition | Intervention |
|---|---|
|
Alcoholism |
Procedure: Magnetic Resonance Imaging (MRI) Behavioral: Interviews, cognitive tests, and emotional measurements |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
| Official Title: | Affective and Conative Changes in Alcoholism |
- Alcoholism's effects on thinking, behavior and brain functioning [ Time Frame: several visits over approximately one month ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 700 |
| Study Start Date: | August 2001 |
| Estimated Study Completion Date: | August 2014 |
| Estimated Primary Completion Date: | August 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
1- MRI and interviews
In our research, we are trying to understand where in the brain these emotional behaviors take place, and whether or not the brain functions differently for alcoholic and nonalcoholic individuals. We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
|
Procedure: Magnetic Resonance Imaging (MRI)
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Behavioral: Interviews, cognitive tests, and emotional measurements
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
|
Detailed Description:
This research investigates brain structure and function in alcoholics compared to healthy nonalcoholic individuals. Alcoholics have shown impairments in cognitive processing of emotional signals. Some alcoholics are impaired in social skills, and many are unable to implement the strategies for interpersonal interactions that they recommend for themselves. For example, alcoholics have difficulty interpreting non-verbal emotional cues and recognizing facial expressions of emotion. When listening to sentences, alcoholics also have some difficulty judging emotional intonations and emotional content. In our research, we are trying to understand where in the brain these emotional behaviors take place, and whether or not the brain functions differently for alcoholic and nonalcoholic individuals. We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Eligibility| Ages Eligible for Study: | 18 Years to 85 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
The study populations include alcoholics and demographically equivalent healthy controls. Potential participants who have participated in one or more of our prior studies are contacted by telephone to determine whether or not they would like to participate again. Potential participants who have not previously been enlisted in any of our studies are recruited through fliers placed in the Boston Veterans Affairs Healthcare System, Boston University School of Medicine, and after-care programs in the Boston area, and through advertisements placed with local newspapers and web sites. For these "new" participants, subject selection procedures include an initial prescreening telephone interview to determine identifying information such as age, level of education, health history, and history of alcohol and drug use. Those eligible are invited to the laboratory for further screening and neuropsychological evaluations.
Inclusion Criteria:
- Male and female right-handed people 18 years of age or older.
- Participants either will have a past Diagnostic and Statistical Manual version IV (DSM-IV) diagnosis of alcohol dependence, or no such history at all.
- Participants will have signed an informed consent.
Exclusion Criteria:
- Pregnant women.
- Shrapnel or other metal in body (dental fillings OK)
Contacts and Locations| Contact: Pooja Parikh, MA | 617-638-5317 | poojap@bu.edu |
| Contact: Marlene O. Berman, PhD | 617-638-4803 | oscar@bu.edu |
| United States, Massachusetts | |
| VA Hospital and Massachusetts General Hospital | Recruiting |
| Boston, Massachusetts, United States, 02130 | |
| Contact: Kayle S. Sawyer, BS 857-364-4003 kslays@bu.edu | |
| Contact: Marlene O. Berman, Ph.D. 857-364-4005 oscar@bu.edu | |
| Principal Investigator: Marlene O. Berman, PhD | |
| Principal Investigator: | Marlene O. Berman, PhD | Boston University |
More Information
Publications:
| Responsible Party: | Marlene Oscar Berman, Professor of Neurology, Psychiatry, and Anatomy & Neurobiology, Boston University |
| ClinicalTrials.gov Identifier: | NCT00300638 History of Changes |
| Other Study ID Numbers: | NIAAABER007112, R01AA007112, NIH Grant R01 AA007112 |
| Study First Received: | March 7, 2006 |
| Last Updated: | November 8, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by Boston University:
|
Alcoholism Emotion Cognition Brain scans |
Additional relevant MeSH terms:
|
Alcoholism Alcohol-Related Disorders Substance-Related Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 16, 2013