Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients - Full Text View

Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

This study has been terminated.
( Number included has been reached )

Sponsored by:	Medical Centre Leeuwarden
Information provided by:	Medical Centre Leeuwarden
ClinicalTrials.gov Identifier:	NCT00298454

Purpose

Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria. Whether or not the administration of diuretics at that moment is appropriate is not known. The study randomises between furosemide or placebo when hemofiltration is stopped. Study endpoint is recovery of renal function.

Condition	Intervention	Phase
Renal Failure Critically Ill	Drug: Furosemide	Phase III

MedlinePlus related topics:

Kidney Failure

ChemIDplus related topics:

Furosemide

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Official Title:	Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh)

Further study details as provided by Medical Centre Leeuwarden:

Primary Outcome Measures:

Creatinin clearance

Secondary Outcome Measures:

length of stay in the intensive care and hospital
intensive care and hospital mortality

Estimated Enrollment:	72
Study Start Date:	December 2005
Study Completion Date:	April 2007

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

cessation of hemofiltration
mechanical ventilation
written informed consent

Exclusion Criteria:

pre-existent renal failure
glomerulonephritis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00298454

Locations


Netherlands, Fr
	Dept of intensive care, Medical Centre Leeuwarden
	Leeuwarden, Fr, Netherlands, 8901 BR

Sponsors and Collaborators

Medical Centre Leeuwarden

Investigators


Principal Investigator:	Peter van der Voort, MD, PhD, MSc	Dept of intensive care, Medical Centre Leeuwarden, PO Box 888,8901BR Leeuwarden, The Netherlands

More Information

Study ID Numbers:	200601
First Received:	March 1, 2006
Last Updated:	April 18, 2007
ClinicalTrials.gov Identifier:	NCT00298454
Health Authority:	Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Medical Centre Leeuwarden:

renal failure

oliguric

critically ill

furosemide

Study placed in the following topic categories:

Renal Insufficiency

Urologic Diseases

Critical Illness

Kidney Diseases

Furosemide

Kidney Failure

Additional relevant MeSH terms:

Membrane Transport Modulators

Disease Attributes

Pathologic Processes

Molecular Mechanisms of Pharmacological Action

Natriuretic Agents

Therapeutic Uses

Physiological Effects of Drugs

Diuretics

Cardiovascular Agents

Sodium Potassium Chloride Symporter Inhibitors

Pharmacologic Actions

ClinicalTrials.gov processed this record on September 05, 2008