Oral Tolerance in Cow’s Milk Allergy in the Infant
Recruitment status was Recruiting
This study aims to determine if there is a link between cow’s milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.
Cow’s milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the same time.
Allergic infants are compared to age matched control group.
Cow’s Milk Allergy
|Study Design:||Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||Oral Tolerance in Cow’s Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora|
|Contact: Florence VILLARD-TRUC, MD||33 472 110 email@example.com|
|Contact: Dominique KAISERLIAN, PhDfirstname.lastname@example.org|
|Lyon, France, 69003|
|Contact: Alain LACHAUX, MD 33 472 110 390 email@example.com|
|Principal Investigator:||Alain LACHAUX, MD||Hospices Civils de Lyon|