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| Sponsored by: |
Hospices Civils de Lyon |
| Information provided by: | Hospices Civils de Lyon |
| ClinicalTrials.gov Identifier: | NCT00298376 |
Purpose
This study aims to determine if there is a link between cow’s milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.
Cow’s milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the same time.
Allergic infants are compared to age matched control group.
| Condition |
|
Cow’s Milk Allergy |
| MedlinePlus related topics: | Allergy |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Case Control, Prospective Study |
| Official Title: | Oral Tolerance in Cow’s Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora |
Eligibility
| Ages Eligible for Study: | 1 Month to 15 Months |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
male or female, age before 6 month, cow’s milk allergy with positive prick or patch test for cow’s milk
Control group: male or female, age before 6 month or within 12 and 18 month, eating cow’s milk every day
Exclusion Criteria:
immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.
Contacts and Locations| Contact: Florence VILLARD-TRUC, MD | 33 472 110 390 | fvillardtruc@hotmail.com |
| Contact: Dominique KAISERLIAN, PhD | kaiserlian@cervi-lyon.inserm.fr |
| France | |||||
| Alain Lachaux | Recruiting | ||||
| Lyon, France, 69003 | |||||
| Contact: Alain LACHAUX, MD 33 472 110 390 alain.lachaux@chu-lyon.fr | |||||
| Hospices Civils de Lyon |
| Principal Investigator: | Alain LACHAUX, MD | Hospices Civils de Lyon |
More Information
| Study ID Numbers: | 2005.389 |
| First Received: | March 1, 2006 |
| Last Updated: | April 26, 2007 |
| ClinicalTrials.gov Identifier: | NCT00298376 |
| Health Authority: | France: Ministry of Health |
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