Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma

This study is not yet open for participant recruitment.

Verified by National Taiwan University Hospital, February 2006

First Received: February 17, 2006 No Changes Posted

Sponsor:	National Taiwan University Hospital
Collaborator:	National Science Council, Taiwan
Information provided by:	National Taiwan University Hospital
ClinicalTrials.gov Identifier:	NCT00294177

Purpose

Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy.

Condition	Intervention	Phase
Trophoblastic Neoplasms Choriocarcinoma	Device: atomic force microscopy Device: dual polarisation interferometry	Phase IV

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study
Official Title:	Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Persistent Gestational Trophoblastic Tumors Using Atomic Force Microscopy and Dual Polarisation Interferometry

Resource links provided by NLM:

MedlinePlus related topics: Cancer

Drug Information available for: Choriogonadotropin Alfa Chorionic gonadotropin

U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment:	30
Study Start Date:	August 2006
Estimated Study Completion Date:	July 2008

Show Detailed Description

Eligibility

Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Clinical diagnosis of trophoblastic neoplasms
Willing to be collected for the urine and 2 ml blood samples

Exclusion Criteria:

Unwilling to be collected for the collect urine or 2ml blood sample

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00294177

Contacts

Contact: Ruey-Jien Chen, MD, PhD

886-2-23123456 ext 5158

rjchen@ha.mc.ntu.edu.tw

Locations

Taiwan
National Taiwan University Hospital Department of Obstetrics and Gynecology
Taipei, Taiwan, 100

Sponsors and Collaborators

National Taiwan University Hospital

National Science Council, Taiwan

Investigators

Principal Investigator:

Ruey-Jien Chen

Department or Obstetrics and Gynecology, National Taiwan university Hospital

More Information

Additional Information:

library of National taiwan University Hospital This link exits the ClinicalTrials.gov site

website of national science council in Taiwan This link exits the ClinicalTrials.gov site

Publications:

Birken S, Armstrong EG, Kolks MA, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL, Canfield RE. Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine. Endocrinology. 1988 Jul;123(1):572-83.

Swann MJ, Peel LL, Carrington S, Freeman NJ. Dual-polarization interferometry: an analytical technique to measure changes in protein structure in real time, to determine the stoichiometry of binding events, and to differentiate between specific and nonspecific interactions. Anal Biochem. 2004 Jun 15;329(2):190-8.

Czajkowsky DM, Hotze EM, Shao Z, Tweten RK. Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18;23(16):3206-15. Epub 2004 Aug 5.

Study ID Numbers:	9561702010, Taiwan NSC 94WFA0101857
Study First Received:	February 17, 2006
Last Updated:	February 17, 2006
ClinicalTrials.gov Identifier:	NCT00294177 History of Changes
Health Authority:	Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:

Trophoblastic Neoplasms
Chorionic Gonadotropin
Molecular Conformation

Additional relevant MeSH terms:

Neoplasms by Histologic Type
Pregnancy Complications, Neoplastic
Pregnancy Complications
Physiological Effects of Drugs
Choriocarcinoma
Hydatidiform Mole
Reproductive Control Agents
Chorionic Gonadotropin
Pharmacologic Actions

Carcinoma
Neoplasms
Therapeutic Uses
Gestational Trophoblastic Neoplasms
Neoplasms, Germ Cell and Embryonal
Trophoblastic Neoplasms
Adenocarcinoma
Neoplasms, Glandular and Epithelial

ClinicalTrials.gov processed this record on February 08, 2010