Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls.

This study has been completed.
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00291993
First received: February 13, 2006
Last updated: April 17, 2008
Last verified: April 2008
  Purpose

Obstructive sleep apnea syndrome is complicated by considerable cardiovascular morbidity and mortality, at least partly due to hypertension. Nocturnal hypoxia, hypercapnia and acidosis stimulate chemoreceptors and presumably increased secretion of vasoactive hormones which might be responsible for hypertension in these patients.

The aim of this study is to measure the secretion of vasoactive hormones at night and to analyse the relationship between vasoactive hormones, oxygen saturation and the blood pressure at night.


Condition Phase
Healthy
Obstructive Sleep Apnea
Phase 4

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Regional Hospital Holstebro:

Study Start Date: January 2004
  Eligibility

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Male and female Age 20-65 Obstructive sleep apnea

Exclusion Criteria:

Drug or alcohol abuse Pregnancy or breast feeding Cancer Clinical signs or history of disease in the heart, lungs, kidney or endocrine organs Abnormal laboratory tests Albuminuria or glucosuria Aterial hypertension for healthy subjects

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00291993

Locations
Denmark
Department of Medical Research, Holstebro Hospital
Holstebro, Ringkoebing County, Denmark, 7500
Holstebro Hospital, Department of Medical Research
Holstebro, Denmark, 7500
Department of Medical Research
Holstebro, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Holstebro Hospital, Department of Medical Research
Principal Investigator: Pia H Hansen, MD Holstebro Hospital, Department of Medical Research
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00291993     History of Changes
Other Study ID Numbers: MED.RES.HOS.2004.01.PHH
Study First Received: February 13, 2006
Last Updated: April 17, 2008
Health Authority: Denmark: Ethics Committee

Keywords provided by Regional Hospital Holstebro:
Obstructive sleep apnea
Vasoactive hormones
Blood pressure

Additional relevant MeSH terms:
Apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Dyssomnias
Sleep Disorders
Nervous System Diseases

ClinicalTrials.gov processed this record on July 28, 2014