Japan Morning Surge-1 Study
The purpose of this study is to examine whether strict blood pressure (BP) control by doxazosin using home BP monitoring, especially targeting the morning BP level, can reduce hypertensive target organ damage.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Effects of Controlling Morning Hypertension on Target Organ Damage With Adrenergic Blockers, Based on Self-Measured Morning Blood Pressure Readings|
- brain natriuretic peptide and the urinary albumin excretion/creatinine ratio at 6 months
|Study Start Date:||August 2003|
|Estimated Study Completion Date:||August 2005|
Morning blood pressure may play an important role in the pathogenesis of hypertensive target organ damage. Increased sympathetic nerve activity is reported to be one of the mechanisms of morning hypertension; however, there are no available data that show whether strict home blood pressure control, especially in the morning period, can reduce target organ damage.We will evaluate whether strict morning blood pressure control by sympathetic nervous system blockade using an alfa-blocker, doxazosin, and with the addition of a beta-blocker if needed, can reduce hypertensive target organ damage.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00285519
|Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine|
|Shimotsuke, Tochigi, Japan, 329-0498|
|Study Chair:||Kazuomi Kario, MD, PhD||Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine|