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| Sponsor: | Rambam Health Care Campus |
|---|---|
| Collaborator: |
Philips Medical Systems |
| Information provided by: | Rambam Health Care Campus |
| ClinicalTrials.gov Identifier: | NCT00285064 |
Purpose
To perform a comprehensive evaluation of multidetector CT myocardial enhancement patterns in patients with an acute ST elevation MI. In particular we plan to assess the relationship between regions with early hypoperfusion and/or late hyperenhancement, and myocardial viability.
| Condition | Intervention |
|---|---|
|
Myocardial Infarction |
Procedure: CT |
| Study Type: | Interventional |
| Study Design: | Diagnostic, Non-Randomized, Single Blind, Uncontrolled, Single Group Assignment |
| Official Title: | Non-Invasive Assessment of Myocardial Viability Using Multidetector Computed Tomography Post Acute Myocardial Infarction |
| Estimated Enrollment: | 20 |
| Study Start Date: | January 2006 |
| Study Completion Date: | May 2008 |
| Primary Completion Date: | August 2007 (Final data collection date for primary outcome measure) |
20 patients admitted to ICCU with ST elevation MI, and treated with primary angioplasty on admission, will undergo between day 2 and 7 post-MI the following exams: a) multidetector CT: regular scan plus late scan at 10 minutes, to evaluate coronary arteries, regional function and myocardial enhancement, b) echocardiography with echo-contrast to evaluate function and size of abnormally contracting region and remodeling, c) nuclear studies: rest early and late Thallium SPECT, to evaluate perfusion and viability. At 3 months a second echo will be performed to assess recovery of abnormal segments. The perfusion defects on MSCT will be compared with the other modalities and at 3 months will be used to evaluate recovery of myocardial function i.e. viability. Parameters that will be evaluated include opacity of hypoenhanced segments, ratio of normal to abnormal segments, change in opacity between early and late scans, size and transmurality of hypoenhanced segments, and their relation to regional contraction.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Israel | |
| Rambam Medical Center | |
| Haifa, Israel, 31096 | |
| Principal Investigator: | Jonathan Lessick, MD DSc | Rambam Health Care Campus |
More Information
| Study ID Numbers: | ram1099_CTIL |
| Study First Received: | January 30, 2006 |
| Last Updated: | October 11, 2008 |
| ClinicalTrials.gov Identifier: | NCT00285064 History of Changes |
| Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
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MDCT viability |
|
Necrosis Heart Diseases Pathologic Processes Myocardial Ischemia Vascular Diseases |
Cardiovascular Diseases Ischemia Infarction Myocardial Infarction |