A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy

This study has been completed.
Sponsor:
Information provided by:
Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
NCT00280332
First received: January 20, 2006
Last updated: May 9, 2008
Last verified: May 2008
  Purpose
  • To determine the prevalence of colonic neoplasm in patients who had previously undergone screening colonoscopy
  • To determine the optimal time interval for re-screening in average risk individuals
  • To determine potential baseline characteristics that predicts adenoma recurrence

Condition Intervention
Colonic Cancer
Procedure: colonoscopy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy

Resource links provided by NLM:


Further study details as provided by Chinese University of Hong Kong:

Primary Outcome Measures:
  • The prevalence of advanced colonic adenoma in the re-screening population [ Time Frame: 5 year from index colonoscopy ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • The time to adenoma adenoma development according to different baseline characteristics of patients and colonoscopy findings [ Time Frame: 5 years from index colonoscopy ] [ Designated as safety issue: No ]

Enrollment: 560
Study Start Date: March 2006
Study Completion Date: November 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
A
colonic adenoma
Procedure: colonoscopy
proform a follow up colonoscopy in the 5 year period from index colonoscopy
Other Name: follow up colonoscopy
B
colonic without adenoma
Procedure: colonoscopy
proform a follow up colonoscopy in the 5 year period from index colonoscopy
Other Name: follow up colonoscopy

Detailed Description:

Colorectal cancer (CRC) is the second commonest cancer in Hong Kong, and tends to be increasing. Screening for colorectal cancer can reduce the cancer incidence and mortality by detecting early lesions. However, the best interval for a follow up colonoscopy, particularly for those with normal baseline colonoscopy, remains largely unknown.

This study aim to determine the prevalence of colonic neoplasm in average-risk patients who had previously undergone screening colonoscopy and the optimal time interval for re-screening.

  Eligibility

Ages Eligible for Study:   50 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Subjects who are previously participated in one of our two screening colonoscopy studies [Sung, Gastroenterol 2003; Leung, AJG 2004]

Criteria

Inclusion Criteria:

  • Subjects who are previously participated in one of our two screening colonoscopy studies [Sung, Gastroenterol 2003; Leung, AJG 2004]
  • Asymptomatic on first screening colonoscopy
  • Age>50and <75
  • No family history of CRC
  • No other colonoscopy except the baseline screening colonoscopy

Exclusion Criteria:

  • Subjects who refused consent
  • Subjects who are not warrant follow up colonoscopy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00280332

Locations
China
Endoscopy Center, Prince of Wales Hospital
Hong Kong (SAR), China
Sponsors and Collaborators
Chinese University of Hong Kong
Investigators
Principal Investigator: Wai K Leung, MD CUHK
  More Information

No publications provided

Responsible Party: Dr WK Leung, Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT00280332     History of Changes
Other Study ID Numbers: FUC
Study First Received: January 20, 2006
Last Updated: May 9, 2008
Health Authority: Hong Kong: Department of Health

Keywords provided by Chinese University of Hong Kong:
colonic adenoma, colonic advanced neoplasm

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases

ClinicalTrials.gov processed this record on July 28, 2014