Alleviation of Cedar Pollen Induced Allergic Symptoms by Orally Taken Superfine Beta-1,3-Glucan
Intravenous- injection of beta-1,3-glucan in human is known to induce T helper type 1 response, while oral uptake did not. It was examined whether superfine dispersed beta-1,3-glucan (SDG) contrived to absorbed by intestinal mucosa would alleviate allergic symptoms by per-oral ingestion
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Prevention
|Official Title:||Alleviation of Cedar Pollen Induced Allergic Symptoms by Orally Taken Superfine Beta-1,3-Glucan - A Double-Blind Randomized Study|
- Symptoms were assessed clinically by score on a allergic symptom rating scale.
- Total IgE and allergen specific IgE were measured.
- The binding capacity of beta-1,3-glucan to peripheral CD14+ cells were assessed.
|Study Start Date:||January 2004|
|Estimated Study Completion Date:||June 2004|
Beta-1,3-glucan made from Japanese mushroom is commercially available for healthy foodstuffs. Allergy patients were orally administrated either SDG (n=30) or non-dispersed beta-1,3-glucan (NDG, n=30) and allergic symptoms were assessed clinically, by the double-blind, placebo-controlled, randomized study
Please refer to this study by its ClinicalTrials.gov identifier: NCT00276445
|Meiji University of Oriental Medicine|
|Kyoto, Japan, 629-0392|
|Principal Investigator:||Jun Yamada, M.D. Ph.D.||Meiji University of Oriental Medicine|
|Study Director:||Junji Hamuro, Ph.D.||Kyoto Prefectural University of Medicine|
|Study Chair:||Shigeru Kinoshita, M.D. Ph.D.||Kyoto Prefectural University of Medicine|