The Importance of Glucagon-Like Peptide-2 (GLP-2)in Mesenteric Bloodflow in Humans
Recruitment status was Recruiting
The purpose of this study is to study the effect of GLP-2 on mesenteric bloodflow in healthy adults by the use of ultrasound., it is the hypothesis that GLP-2 vil increase the bloodflow.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Health Services Research
|Official Title:||The Importance of Glucagon-Like Peptide-2 (GLP-2)in Mesenteric Bloodflow in Humans|
|Study Start Date:||January 2006|
The investigation will include 10 testpersons.
It will be a 2 fase study over 2 days.
day 1: The testperson will meet fasting, and take in a standard liquid meal, after this the bloodflow in a mesenteric artery will be measured by use of ultrasonic technique. Bloodsamples will be taken regular in a total wolumne of 200 ml.
day 2:The testperson will meet fasting, there wil be administered intraveneous GLP-2 in 3 increasing doses over 3 x 45 min.and one subcutaneous dose. During this the bloodflow in a mesenteric artery will be measured by use of ultrasonic technique. Bloodsamples will be taken regular in a total wolumne of 200 ml.
|Contact: Lasse Bremholm Hansen, MDfirstname.lastname@example.org|
|Copenhagen, Copenhagen City, Denmark, 2100|
|Contact: Lasse Bremholm Hansen, MD 004560927874 email@example.com|
|Sub-Investigator: Mads Hornum, MD|
|Principal Investigator:||Mads Hornum, MD||Glostrup University Hospital, Copenhagen|