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The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells
This study has been completed.
Study NCT00272571   Information provided by Sheba Medical Center
First Received: January 4, 2006   Last Updated: January 29, 2006   History of Changes

January 4, 2006
January 29, 2006
August 2004
 
The number of circulating endothelial progenitor cells in peripheral blood (before and one week after treatment)
Same as current
Complete list of historical versions of study NCT00272571 on ClinicalTrials.gov Archive Site
  • Brachial artery endothelial function (before and one week after treatment)
  • CCS angina class (before and one week after treatment)
  • Brachial artery endothelial function before and one week after treatment)
  • CCS angina class (before and one week after treatment)
 
The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells
The Effects of External Counter Pulsation Therapy (ECPT) on the Number and Function of Circulating Endothelial Progenitor Cells in Patients With Angina Pectoris

The objectives of the study are to test the hypothesis that external counter pulsation therapy (ECPT) provides clinical benefit by improving the number and function of endothelial progenitor cells (EPCs) in peripheral blood of patients with angina pectoris.

ECPT is a non-invasive approach for increasing blood flow to the heart in patients with myocardial ischemia. ECPT produces beneficial effects in coronary artery disease (CAD) patients. However, the exact mechanisms of ECPT action are not defined yet. Evidence has now accumulated that bone marrow-derived cells with angiogenic capability, termed EPCs, circulate in the blood of adults. EPCs possess the ability to home to sites of ischemia and contribute to neoangiogenesis.

We prospectively study CAD patients [Canadian Cardiovascular Society (CCS) angina class II-IV], before and after ECPT , and compare them with age- and sex-matched controls. Peripheral blood CD34+ cells, EPCs (CD34/VEGFR2+ cells), EPC colony forming units (CFUs) and brachial artery endothelial function is assessed prior to and after ECPT. Percent improvement in endothelium-dependent brachial artery flow-mediated dilatation (%FMD) is assessed using high-resolution ultrasound.

 
Interventional
Treatment, Non-Randomized, Open Label, Active Control, Crossover Assignment
Coronary Artery Disease
Procedure: External counter pulsation therapy
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
25
January 2006
 

Inclusion Criteria:

  • coronary artery disease
  • CCS angina class II-IV

Exclusion Criteria:

  • aortic regurgitation
  • acute myocardial infarction <3 months
  • systemic hypertension >180/110 mm
  • atrial fibrillation
  • deep vein thrombosis
  • phlebitis and hemorrhagic diathesis
  • pregnancy
  • abdominal aortic aneurism
  • metastatic tumor
Both
40 Years to 90 Years
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
NCT00272571
 
SHEBA-02-2701-JL-CTIL
Sheba Medical Center
 
Principal Investigator: Jonathan Leor, Prof. Chaim Sheba Medical Center
Sheba Medical Center
January 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP