FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.

This study has been completed.
Sponsor:
Information provided by:
Scios, Inc.
ClinicalTrials.gov Identifier:
NCT00270361
First received: December 22, 2005
Last updated: July 25, 2011
Last verified: July 2011
  Purpose

The purpose of this study is to assess the safety and tolerability of two doses of nesiritide (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) when administered serially as a treatment to outpatients with worsening congestive heart failure (decompensated CHF) who are receiving their usual cardiac medications and are at high risk for hospitalization.


Condition Intervention Phase
Heart Failure, Congestive
Drug: nesiritide
Drug: usual long term cardiac medications
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Management of Patients With CHF After Hospitalization-Follow up Serial Infusions of NATRECOR (Nesiritide) - FUSION I, A Pilot Study

Resource links provided by NLM:


Further study details as provided by Scios, Inc.:

Primary Outcome Measures:
  • Safety and tolerability of treatment of nesiritide as an adjunct to standard medical therapy

Secondary Outcome Measures:
  • In NYHA Class IV patients with renal disease; number of hospitalizations, deaths, adverse cardiovascular events, and, adverse renal events

Enrollment: 214
Study Start Date: December 2001
Study Completion Date: January 2003
Arms Assigned Interventions
Experimental: 001
nesiritide
Drug: nesiritide
Experimental: 002
nesiritide
Drug: nesiritide
Active Comparator: 003
usual long term cardiac medications
Drug: usual long term cardiac medications

Detailed Description:

Efforts to contain rising costs for hospital acute care have resulted in shorter hospital stays for patients with acutely decompensated heart failure. These shorter stays may not allow for adequate diuresis, titration of oral medications, or for patients to receive the full benefit of intravenously (IV) administered medications. In addition to shorter stays when hospitalized, physicians are exploring ways to treat patients in the outpatient setting to avoid hospitalization. Although there is increasing interest among clinicians in the use of outpatient IV therapy for the treatment of advanced heart failure, there is no consensus among clinicians regarding patient selection, dosing, or treatment duration. The use of IV inotropic agents (drugs that influence and or affect muscle contractility) such as milrinone or dobutamine in this setting is controversial and may lead to increased mortality. Indeed, the ACC/AHA (American College of Cardiology and American Hospital Association) guidelines warn that long-term intermittent use of IV inotropes for treatment of left ventricular dysfunction is of "unproved value and not recommended." Yet, despite these guidelines, clinicians use inotropes in the outpatient setting because there is no currently approved alternative therapy. Thus, there is an unmet need for effective outpatient treatment of advanced chronic heart failure to improve quality of life and/or reduce the number of hospital admissions for heart failure.

The data from previous studies suggest that doses of NATRECOR® hBNP may be a potent agent for the treatment of acute congestive heart failure (CHF) with a unique combination of desirable effects on the flow of blood throughout the body; the hormones secreted by the nervous system and support of copious salt outputs by the renal system not provided by currently available therapies. This study is a multicenter, open-label pilot study in which subjects who have received treatment for acutely decompensated CHF during a hospitalization at least twice within the previous 12 months are randomized (1:1:1) to one of three treatment groups. One treatment group will receive their usual long term cardiac medications, either with or without serial infusions of inotropes (various drugs that affect the strength of contractions of the heart muscle) and without nesiritide therapy. The 0.005 mcg/kg/min nesiritide treatment group receives a 0.5 mcg/kg bolus of nesiritide followed by a 0.0025 mcg/kg/min infusion, in addition to their usual long term cardiac medications, excluding IV inotropes; The 0.010 mcg/kg/min nesiritide treatment group receives a 1 mcg/kg bolus of nesiritide followed by a 0.005 mcg/kg infusion, in addition to their usual long term cardiac medications, excluding IV inotropes. Because patients treated in an outpatient setting may be less decompensated than patients with acutely decompensated heart failure, this study was designed to evaluate the 0.010 mcg/kg/min dose of nesiritide (the currently approved dose for acutely decompensated patients) as well as a lower dose (0.005 mcg/kg/min).

The hypothesis is that as an adjunct therapy to oral medications, serial IV infusions of nesiritide may produce more rapid and sustained compensation of heart failure in patients with frequent episodes of decompensated heart failure. The 0.005 mcg/kg/min group receives a 0.5 mcg/kg bolus followed by a 0.0025 mcg/kg/min infusion; the 0.010 mcg/kg/min group receives a 1 mcg/kg bolus followed by a 0.005 mcg/kg infusion. Intravenous bolus over 60 seconds and a fixed rate infusion of 4 - 6 hours, at least once per week for 12 weeks.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subjects having had at least two hospital admissions (or equivalent treatment) for acutely decompensated CHF within the last 12 months, with at least one of these admissions in the past 30 days, and having received treatment with intravenous vasoactive agents (such as intravenous inotropes, NATRECOR®, or nitroglycerin)
  • able to be enrolled and initiate treatment with study drug within 5 to 30 days of last hospital discharge (or equivalent treatment) of acutely decompensated CHF
  • have a baseline NYHA (New York Heart Association) Functional Classification III or IV for at least 2 months prior to randomization
  • currently receiving optimal treatment with long term oral medications (e.g., diuretics, ACE inhibitors, and beta blockers, unless beta blockers or ACE inhibitors are documented to be contraindicated or not tolerated)
  • willing to receive infusions of NATRECOR®, or possibly other medications, at least as frequently as once per week for 12 weeks.

Exclusion Criteria:

  • Subjects having systolic blood pressure consistently less than 90 mm Hg
  • having had organ transplantation (heart, liver, lung and kidney) in the past or anticipating organ transplantation during the study
  • not able or willing to discontinue intermittent or continuous infusions of inotropes if randomized to a NATRECOR® treatment group
  • having had a bi-ventricular pacemaker placed within the past 60 days or an automatic implantable cardiac defibrillator placed within the past 30 days
  • requiring chronic dialysis or have an expectation that dialysis will be required during the course of the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00270361

Sponsors and Collaborators
Scios, Inc.
Investigators
Study Director: Scios, Inc. Clinical Trial Scios, Inc.
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00270361     History of Changes
Obsolete Identifiers: NCT00040612
Other Study ID Numbers: CR003316, NATRECORHFA2001
Study First Received: December 22, 2005
Last Updated: July 25, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Scios, Inc.:
Heart Failure
Renal Dysfunction
Cardiomyopathy
Heart Decompensation
Dyspnea Paroxsymal
Outpatient Therapy.

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on September 14, 2014