Inclusion Criteria:

• Subject is healthy, as determined by medical history.
• Subject is between the ages of 15 and 23 years (not yet 24 years).
• For subjects who participated in Study MTA02, subject previously received one dose of Menactra® vaccine or Menomune®-A/C/Y/W-135 vaccine.
• Did not participate in Study MTA19 (a subset of subjects from Study MTA02 who had been recruited for a follow-up challenge study)
• Subject or parent/legal guardian has signed an Institutional Review Board (IRB)-approved informed consent form and subject has signed an IRB-approved assent form.
• Before recruitment for the second part of the study, subjects should be thoroughly screened to ensure that they are able to comply with protocol specifications
• A negative urine pregnancy test is required for menstruating female subjects.

Exclusion Criteria:

• History of documented invasive meningococcal disease.
• Received any other meningococcal vaccine
• Received any vaccine (other than desensitization therapy for allergies) in the 28-day period prior to enrollment
• Scheduled to receive any vaccination in the 28-day period after enrollment
• Received systemic antibiotic therapy within the 72 hours prior to collection of a blood sample
• Actively enrolled or scheduled to be enrolled in another clinical study
• Serious chronic disease (i.e., cardiac, renal, neurologic, rheumatologic, metabolic, gastrointestinal, hematologic, psychiatric, or other organ system)
• Known or suspected impairment of immunologic function
• Acute medical illness with or without fever within 72 hours or an oral temperature >= 100.4°F (>= 38.0°C) at the time of inclusion
• Administration of immune globulin, other blood products, or corticosteroid within 3 months of the study vaccine. Individuals on a tapering dose schedule of oral steroids lasting < 7 days may be included in the trial as long as they have not received more than one course within the last two weeks prior to enrollment.
• Personal or family history of Guillain-Barre Syndrome
• Suspected or known hypersensitivity to any of the vaccine components
• Unavailable for the entire study period or unable to attend the scheduled visits or to comply with the study procedures
• Any condition, which in the opinion of the investigator would pose a health risk to the participant.