Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole

This study has been completed.
Sponsor:
Information provided by:
Radboud University
ClinicalTrials.gov Identifier:
NCT00268554
First received: December 21, 2005
Last updated: March 27, 2008
Last verified: March 2008
  Purpose

The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. Furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.


Condition Intervention
Hyperemia
Hypoxia
Drug: dipyridamole
Drug: caffeine

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Enhancement of Postocclusive Reactive Hyperaemia

Resource links provided by NLM:


Further study details as provided by Radboud University:

Primary Outcome Measures:
  • forearm blood flow

Estimated Enrollment: 12
Study Start Date: December 2005
Study Completion Date: July 2006
  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy volunteers between 18 and 50 years

Exclusion Criteria:

  • none specified
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00268554

Locations
Netherlands
Radboud university Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6533 ZA
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Gerard Rongen, MD,PhD Radboud University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00268554     History of Changes
Other Study ID Numbers: PORH-dipy
Study First Received: December 21, 2005
Last Updated: March 27, 2008
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Radboud University:
adenosine
caffeine
dipyridamole

Additional relevant MeSH terms:
Hyperemia
Vascular Diseases
Cardiovascular Diseases
Dipyridamole
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Platelet Aggregation Inhibitors
Hematologic Agents
Therapeutic Uses
Vasodilator Agents
Cardiovascular Agents

ClinicalTrials.gov processed this record on September 30, 2014