Myopia Progression and the Effect of 7-Methylxanthine
Recruitment status was Active, not recruiting
7-methylxanthine has been shown to increase the concentration and thickness of collagen fibrils in rabbit sclera. Deficient collagen in the sclera may be the cause of progression of childhood myopia. The study hypothesis is that treatment with 7-methylxanthine will stabilize the sclera and prevent further progression of myopia.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
|Official Title:||Phase 2 Study of the Effect of 7-Methylxanthine on the Progression of Childhood Myopia|
- Axial growth
- Myopia progression
|Study Start Date:||October 2003|
|Estimated Study Completion Date:||March 2006|
Participants are given tablets of 7-methylxanthine 400 mg per day or placebo tablets for 12 months. Axial length, cycloplegic refraction and corneal curvature is measured, as well as weight, height, blood pressure and heart rate. The participants are interviewed about possible CNS, gastrointestinal, or cardiopulmonal side effects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00263471
|Study Chair:||Klaus Trier, MD||Trier Research Laboratories|