Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by National Health Research Institutes, Taiwan.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborators:
National Taiwan University Hospital
Taipei Veterans General Hospital, Taiwan
Chang Gung Memorial Hospital
Taichung Veterans General Hospital
National Cheng-Kung University Hospital
Kaohsiung Medical University
Information provided by:
National Health Research Institutes, Taiwan
ClinicalTrials.gov Identifier:
NCT00260871
First received: December 1, 2005
Last updated: July 27, 2011
Last verified: July 2011
  Purpose

Lung adenocarcinoma in Chinese females is hypothesized to be determined by both genetic and environmental factors. In this grant proposal, we propose to map the loci of susceptibility genes of female lung adenocarcinoma based on multiplex families recruited in Taiwan. We focus on a unique pathological type of a unique population in order to reduce heterogeneity of the genetic background. Compared with western women, female Chinese population has a high prevalence of lung adenocarcinoma. Our reasoning is that if we focus on a specific sub-type, which has a familial basis, we will increase the probability of identifying genes associated with female lung adenocarcinoma. The primary goal of this study is to identify the genetic and environmental determinants of female lung adenocarcinoma, and study the relationship between gene polymorphisms and clinical manifestation profiling of lung cancer.


Condition
Lung Cancer

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications-focusing on Female Lung Adenocarcinoma (GEFLAC)

Resource links provided by NLM:


Further study details as provided by National Health Research Institutes, Taiwan:

Estimated Enrollment: 1500
Study Start Date: May 2002
Detailed Description:

This research proposal intends to integrate epidemiologists, biostatisticians, clinicians, molecular biologists/geneticists to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma, and to study the relationship between gene polymorphisms and clinical outcomes of lung cancer patients. Our objective is to find gene markers for developing useful screening tools for the high risk group in order to prevent or early detect lung cancer, especially female lung adenocarcinoma.

The specific aims of this subproject include:

  1. Establish and maintain the research network that will recruit and follow up the subjects and families for the GEFLAC study; keeping control of the progress of the study.
  2. Coordinate all the subprojects such as integrating genotyping data with clinical data and environment data.
  3. Continue to employ the candidate gene approach to examine the contribution of specific genes to the lung cancer.
  4. Generate genotyping data for candidate genes in the exploring stage and prioritize SNPs of candidate genes for large scale studies.
  5. Identify susceptible genes/candidate genes to develop multiplex PCR for screening.
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The program project intend to identify susceptible genes for lung cancer, especially for female lung adenocarcinoma.

Criteria

Inclusion Criteria:

  • lung adenocarcinoma

Exclusion Criteria:

-

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00260871

Locations
Taiwan
Division of Biostatistics and Bioinformatics, NHRI
Miaoli county, Taiwan, 350
Sponsors and Collaborators
National Health Research Institutes, Taiwan
National Taiwan University Hospital
Taipei Veterans General Hospital, Taiwan
Chang Gung Memorial Hospital
Taichung Veterans General Hospital
National Cheng-Kung University Hospital
Kaohsiung Medical University
Investigators
Study Director: Chao Hsiung, PhD NHRI
  More Information

Additional Information:
No publications provided

Responsible Party: Dr. Chao Agnes Hsiung, Institute of Population Health Sciences, National Health Research Instiutes, Taiwan
ClinicalTrials.gov Identifier: NCT00260871     History of Changes
Other Study ID Numbers: 94LCP005, 1.DOH-94-TD-G-111-025, 2.DOH-94-TD-G-111-027
Study First Received: December 1, 2005
Last Updated: July 27, 2011
Health Authority: Taiwan: Department of Health

Keywords provided by National Health Research Institutes, Taiwan:
lung adenocarcinoma
genetic epidemiology
environmental factors
genetic map
coordination center

Additional relevant MeSH terms:
Lung Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Adenocarcinoma
Carcinoma
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on July 22, 2014