Brain Abnormalities in Late-Onset Major Depression

This study has been completed.
Sponsor:
Collaborators:
The Danish Medical Research Council
Bayer
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00260468
First received: November 30, 2005
Last updated: October 21, 2009
Last verified: October 2009
  Purpose

The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging (MRI), neuropsychological testing, neurological examination, eye examination as well as blood and saliva samples. The results are to be compared with results from a control group matched for gender and age.


Condition Intervention
Major Depression
Other: Clinical examination program

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Structural and Functional Cerebral Findings in Late-Onset Major Depression

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Biospecimen Retention:   Samples With DNA

Apolipoprotein


Enrollment: 44
Study Start Date: November 2005
Study Completion Date: December 2008
Intervention Details:
    Other: Clinical examination program
    Psychiatric/clinical interview MRI scan Blood samples Saliva samples Eye examination
Detailed Description:

Major depression is a frequent and serious disorder with different prognoses and complications with respect to lack of treatment response, recurrence and suicide.

MRI of the brain can provide information about changes in the brain tissue with depression, e.g. lesions of nerve connections, small thrombi or changes in the blood flow. These changes appear primarily after the age of 50 and are seen in cases of diabetes and high blood pressure. Furthermore, the connection between disruptions in the body's stress response system and depression will be explored, which is very important since studies indicate that stress and depression can affect certain brain parts permanently. This will give us a better understanding of the connection between brain changes, neuropsychology and depression prognosis, which is decisive for accurate diagnostics, effective treatment and targeted prevention of the disease in the long run.

The project is part of a larger clinical assessment programme in the Neuropsychiatric Unit under the Centre for Basic Psychiatric Research, Aarhus Psychiatric Hospital, Denmark, which gives us unique possibilities of combining research and daily clinical work. The hope is in the future to be able to offer patients in the risk group better assessment and treatment to prevent complications and recurrence.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  1. Subjects with first-episode late-onset major depression from psychiatric hospital or clinic
  2. Healthy controls
Criteria

Inclusion Criteria:

  • first time major depression
  • age over 50 years
  • Caucasian
  • admitted at a psychiatric hospital or treated at a local psychiatric clinic in Aarhus Amt

Exclusion Criteria:

  • major brain damage (e.g. stroke, epilepsy, trauma)
  • major alcohol or drug abuse
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00260468

Locations
Denmark
Centre for Psychiatric Research, Aarhus University Hospital
Risskov, Denmark, DK-8240
Sponsors and Collaborators
University of Aarhus
The Danish Medical Research Council
Bayer
Investigators
Study Director: Raben Rosenberg, Professor, MD, DrMedSc Aarhus University Hospital
Principal Investigator: Videbech Poul, Professor, MD, DrMedSc Aarhus University Hospital
Study Chair: Leif Østergaard, Professor, MD, DrMedSc, PhD Center for Functionally Integrative Neuroscience (CFIN), Aarhus University Hospital, Denmark
  More Information

No publications provided

Responsible Party: Professor Poul Videbech, MD, DrMedSc, Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denamrk
ClinicalTrials.gov Identifier: NCT00260468     History of Changes
Other Study ID Numbers: 20051050
Study First Received: November 30, 2005
Last Updated: October 21, 2009
Health Authority: Denmark: National Board of Health

Keywords provided by University of Aarhus:
Major depression
Magnetic resonance imaging
White matter lesions
Perfusion
Diffusion
Magnetization transfer
Vascular risk factors

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 30, 2014