This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).
Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
|Official Title:||Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.|
|Study Start Date:||June 2005|
|Estimated Study Completion Date:||September 2005|
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.
|United States, Connecticut|
|Yale School of Medicine|
|New HAven, Connecticut, United States, 06510|
|Principal Investigator:||David G Silverman||Yale School of Medicine|