Microvascular Reactivity.

This study has been completed.
Sponsor:
Information provided by:
Yale University
ClinicalTrials.gov Identifier:
NCT00259701
First received: November 28, 2005
Last updated: October 5, 2006
Last verified: November 2005
  Purpose

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).


Condition Intervention
Diabetes
Retinopathy
Vascular Pathology
Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Resource links provided by NLM:


Further study details as provided by Yale University:

Estimated Enrollment: 20
Study Start Date: June 2005
Estimated Study Completion Date: September 2005
Detailed Description:

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

-

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00259701

Locations
United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510
Sponsors and Collaborators
Yale University
Investigators
Principal Investigator: David G Silverman Yale School of Medicine
  More Information

No publications provided by Yale University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00259701     History of Changes
Other Study ID Numbers: HIC-12397-1
Study First Received: November 28, 2005
Last Updated: October 5, 2006
Health Authority: United States: Institutional Review Board

Keywords provided by Yale University:
endothelium
iontophoresis
acetylcholine
nitroglycerin
vasodilation

Additional relevant MeSH terms:
Nitroglycerin
Acetylcholine
Vasodilator Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on September 16, 2014