Microvascular Reactivity. - Full Text View

Purpose

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition	Intervention
Diabetes Retinopathy Vascular Pathology	Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

MedlinePlus related topics:

Retinal Disorders

ChemIDplus related topics:

Acetylcholine Acetylcholine chloride Nitroglycerin

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study

Official Title:	Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Further study details as provided by Yale University:

Estimated Enrollment:	20
Study Start Date:	June 2005
Estimated Study Completion Date:	September 2005

Detailed Description:

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

-

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00259701

Locations


United States, Connecticut
	Yale School of Medicine
	New HAven, Connecticut, United States, 06510

Sponsors and Collaborators

Yale University

Investigators


Principal Investigator:	David G Silverman	Yale School of Medicine

More Information

Publications indexed to this study:

Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. Yale J Biol Med. 2006 Mar;79(1):1-7.

Study ID Numbers:	HIC-12397-1
First Received:	November 28, 2005
Last Updated:	October 5, 2006
ClinicalTrials.gov Identifier:	NCT00259701
Health Authority:	United States: Institutional Review Board

Keywords provided by Yale University:

endothelium

iontophoresis

acetylcholine

nitroglycerin

vasodilation

Study placed in the following topic categories:

Nitroglycerin

Eye Diseases

Diabetes Mellitus

Acetylcholine

Retinal Diseases

Additional relevant MeSH terms:

Vasodilator Agents

Neurotransmitter Agents

Molecular Mechanisms of Pharmacological Action

Therapeutic Uses

Physiological Effects of Drugs

Cardiovascular Agents

Cholinergic Agents

Pharmacologic Actions

ClinicalTrials.gov processed this record on October 10, 2008

Sponsored by:	Yale University
Information provided by:	Yale University
ClinicalTrials.gov Identifier:	NCT00259701