Functional Lipids and Appetite Regulation

This study has been completed.
Sponsor:
Collaborator:
Danisco
Information provided by:
University of Copenhagen
ClinicalTrials.gov Identifier:
NCT00259259
First received: November 28, 2005
Last updated: January 20, 2009
Last verified: September 2006
  Purpose

To evaluate the short-term effects of structured lipids on appetite regulation.


Condition Intervention
Obesity
Behavioral: SALATRIM

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: The Effect of Functional Lipids on Appetite Regulation in Man

Resource links provided by NLM:


Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • Appetite
  • energy intake
  • Hormones

Secondary Outcome Measures:
  • Palability

Estimated Enrollment: 22
Study Start Date: October 2005
Estimated Study Completion Date: December 2005
Detailed Description:

Background Obesity is a major health problem worldwide, and it is a risk factor for several chronic disorders. Even small changes in energy intake, leading to a positive balance may lead to weight gain over time. Thus, slight modifications in food intake, such as the inclusion of foods that effect energy balance, may prevent weight gain and even facilitate weight loss. Replacing dietary fat with low-calorie fat (LCF), such as modified triglycerides with medium and long chained PUFA.may be an efficient way to reduce body fat.

Bray et al. (2002) has shown a sustained weight loss of ~6 kg over a 9 month period where one-third of a fat-reduced diet (25% fat) was replaced by olestra. This weight loss can not solely be explained by the decreased caloric content of olestra. Thus, inhibition of appetite leading to lower food intake, may be a potential mechanism of the observed weight loss.

A reduced absorption of LCF leaves undigested fatty acids in the middle and lower intestine, which may generate increased feelings of satiety and decrease caloric intake due to regulating peptides and hormones such (CCK, GLP-1, etc.). In addition, intraduodenal fatty acids may also promote distension of the stomach and distension of the intestine, which are well-known gastrointestinal signals controlling mechanisms for food intake.

Taken together, in addition to the acute reduction in caloric intake, LCF may encourage a gastrointestinal hormone response promoting beneficial effects on appetite regulation and energy balance.

Aims To evaluate the short-term effects of LCF on

Primary:

  • Appetite sensations after a meal (VAS)
  • Postprandiel secretion of appetite regulating hormones
  • Ad libitum caloric intake 4,5-h subsequent to a fixed meal

Secondary:

• Palatability of the test meal

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males
  • Normal weigh, e.i. BMI between 18,5-25 kg/m2
  • age 18-40 years

Exclusion Criteria:

  • donation of blood 3 monhts prior or during the study
  • gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease
  • smoking
  • consumption of more than 21 alcoholic drinks/week
  • elite athletes
  • on mediation
  • diet supplements
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00259259

Locations
Denmark
Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg C, Copenhagen, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
Danisco
Investigators
Principal Investigator: Arne Astrup, Proffessor Department of human nutrition, The Royal Veterinary and Agricultural University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00259259     History of Changes
Other Study ID Numbers: (KF) 01 275625, B218
Study First Received: November 28, 2005
Last Updated: January 20, 2009
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by University of Copenhagen:
Appetite regulation
Hormones
Energy intake

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on July 23, 2014