A Protocol for the Use of Chlorhexidine Gluconate Saturation for the Reduction of Dental Biofilm Formation on Polymethylmethacrylate Restoration

This study has been completed.
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00259181
First received: November 24, 2005
Last updated: January 5, 2010
Last verified: December 2007
  Purpose

Chlorhexidine gluconate (CHX), as an anti plaque agent, is commonly used with a variety of products. In this study we, the investigators at Hadassah Medical Organization, intend to examine the efficacy of a single dip in CHX of provisional restoration prior to oral cementation. If the protocol is effective, we intend to calibrate it and recommend clinical use of the protocol. The examination of biofilm formation will be both with electron microscope and confocal scanning laser microscope.


Condition Intervention Phase
Dental Plaque
Procedure: saturation of polymethylmethacrylate with chlorhexidine gluconate to reduce in vivo plaque formation
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Prevention
Official Title: Examination of the Immersion of Provisional Crown Material in Chlorhexidine Gluconate on Dental Plaque Formation in Vivo

Resource links provided by NLM:


Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • calibration of a preventative protocol for biofilm formation measured by confocal scanning laser microscope and scanning electron microscope

Estimated Enrollment: 12
Study Start Date: January 2005
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Any volunteer without systemic condition

Exclusion Criteria:

  • Intake of antibiotic drug three months prior to experiment
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00259181

Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel, 91120
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Study Director: Michael M Perez Davidi, DMD Hadassah Medical Organization
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00259181     History of Changes
Other Study ID Numbers: 191058HMO-CTIL
Study First Received: November 24, 2005
Last Updated: January 5, 2010
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
chlorhexidine gluconate
polymethylmethacrylate
Anti-Bacterial Agents

Additional relevant MeSH terms:
Dental Plaque
Dental Deposits
Tooth Diseases
Stomatognathic Diseases
Polymethyl Methacrylate
Chlorhexidine
Chlorhexidine gluconate
Vasodilator Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Antimutagenic Agents
Protective Agents
Physiological Effects of Drugs
Anti-Infective Agents, Local
Anti-Infective Agents
Disinfectants
Dermatologic Agents

ClinicalTrials.gov processed this record on April 17, 2014