Morphofunctional Imaging and Developmental Dyslexia (PHRR04-CH/DYS)

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT00254644
First received: November 15, 2005
Last updated: May 2, 2011
Last verified: May 2011
  Purpose

Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.


Condition Intervention
Developmental Dyslexia
Procedure: Morphological and functional MRI

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by University Hospital, Tours:

Primary Outcome Measures:
  • Cortical thickness [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages


Secondary Outcome Measures:
  • Average cortical thickness [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.


Enrollment: 32
Study Start Date: February 2007
Study Completion Date: May 2009
Groups/Cohorts Assigned Interventions
Dyslexia
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time
Control
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

This is a prospective study including 15 right-handed male subjects, aged 18 to 35 years, carrying a developmental dyslexia and 15 control subjects handed the same sex. We chose to include only male subjects to obtain a homogeneous population and to avoid the problem of a functional organization differs according to gender.

Criteria

Inclusion Criteria:

  • Developmental dyslexia according to Critchley.
  • Normal performance intelligence quotient (PIQ)
  • Age: 18-35 years
  • Sex: Male
  • Right handed
  • No hearing deficit.

Exclusion Criteria:

  • No head injury
  • No attention deficit hyperactivity disorder (ADHD)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00254644

Locations
France
CHU
Tours, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Investigators
Principal Investigator: Frédérique Bonnet-Brilhault CHU Tours
  More Information

No publications provided

Responsible Party: University Hospital Tours
ClinicalTrials.gov Identifier: NCT00254644     History of Changes
Other Study ID Numbers: PHRR04-CH/DYS
Study First Received: November 15, 2005
Last Updated: May 2, 2011
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by University Hospital, Tours:
phonological treatment
language
fMRI

Additional relevant MeSH terms:
Dyslexia
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on July 26, 2014