Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2005 by Far Eastern Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00247533
First received: October 31, 2005
Last updated: February 6, 2009
Last verified: August 2005
  Purpose

There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass surgery (CABG) or percutaneous coronary intervention. Perfusion defect on nuclear brain scan is also noted to correlate with these neurological complications. On the other hand, the perioperative arrhythmia and following cerebral embolism was also attributed to be one factor inducing such neurological hazards.

In the patients with coexistent CAD and CAS (1st group), and also the patients scheduled for CABG or percutaneous coronary intervention (PCI) (2nd group), we, the researchers at Far Eastern Memorial Hospital, attempted to integrate all the parameters mention above, including angiography of coronary and cerebral system, quantitative analysis of nuclear brain scan, biochemical profile, and signals of a new ambulatory device which could record the electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, in order to define the correlation between them. A chorological relation between EEG signals and ECG signals is our first target to be worked out. Thereafter, we hope to establish a regression model of all involved parameters according to the relation. Such a model, we believe, is essential not only to explain the post-CABG neurological complications, but to prevent them.

Furthermore, for the undetermined ischemic stroke patients who had no obvious culprit artery or embolism source, the paroxysmal arrhythmia had long been regarded as the cause. Whether a paroxysmal atrial fibrillation, which had not been disclosed by routine ECG, could induce most of such a stroke is still not known. With this new ambulatory device which could record the electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, we want to answer the question.


Condition Intervention Phase
Stroke
Coronary Artery Disease
Arrhythmia
Procedure: Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic
Official Title: The Early Diagnosis and Prevention of Ischemic Stroke and Cognition Decline Associated With Coronary Artery Disease Combined With Cerebral Artery Stenosis or Arrhythmia by 24-Hour Simultaneous Recorder of Electrocardiograph and Electroencephalography

Resource links provided by NLM:


Further study details as provided by Far Eastern Memorial Hospital:

Estimated Enrollment: 30
Study Start Date: October 2005
Estimated Study Completion Date: August 2007
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Coronary artery stenosis >50% and either carotid or brain artery stenosis > 50%

Exclusion Criteria:

  • Creatinine > 2.0 mg/dL
  • Co-morbidity
  • ER
  • A letter of authorization is not given
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00247533

Contacts
Contact: A H Li, MD 886-2-8966-7000 ext 1113 las1012.tw@yahoo.com.tw

Locations
Taiwan
Far Eastern Memorial Hospital Recruiting
Taipei, Taiwan, 220
Contact: A H Li, MD    886-2-8966-7000 ext 1113    las1012.tw@yahoo.com.tw   
Principal Investigator: A H Li, MD         
Sponsors and Collaborators
Far Eastern Memorial Hospital
Investigators
Principal Investigator: A H Li, MD Far Eastern Memorial Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00247533     History of Changes
Other Study ID Numbers: FEMH-E-940004
Study First Received: October 31, 2005
Last Updated: February 6, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by Far Eastern Memorial Hospital:
coronary disease
cerebrovascular disorders
angiography
cerebral ischemia
intracranial atherosclerosis
Coronary artery disease
cerebral artery stenosis
percutaneous coronary balloon angioplasty
coronary artery bypass surgery
ischemic stroke
electrocardiograph
electroencephalograph
Nuclear brain scan
cognition decline
atrial fibrillation
undetermined ischemic stroke

Additional relevant MeSH terms:
Cerebral Infarction
Coronary Artery Disease
Coronary Disease
Coronary Stenosis
Myocardial Ischemia
Stroke
Arterial Occlusive Diseases
Arteriosclerosis
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Heart Diseases
Nervous System Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on October 21, 2014