To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by St George's, University of London.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
The Stroke Association, United Kingdom
Information provided by:
St George's, University of London
ClinicalTrials.gov Identifier:
NCT00238667
First received: October 11, 2005
Last updated: October 16, 2006
Last verified: September 2005
  Purpose

This is a feasibility study to determine if a sufficient number of patients can be recruited throughout the United Kingdom and whether sufficient endpoints can be generated for a full scale therapeutic trial of anticoagulants versus antiplatelets in acute cervical artery dissection treatment.


Condition
Cervical Artery Dissection
Carotid Artery Dissection
Vertebral Artery Dissection
Stroke

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Cervical Artery Dissection in Stroke Study

Resource links provided by NLM:


Further study details as provided by St George's, University of London:

Estimated Enrollment: 250
  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Extracranial carotid or vertebral artery dissection with symptom onset within the last 7 days. This includes:

    1. Ipsilateral transient ischemic attack or stroke
    2. Ipsilateral Horner's syndrome or neck pain with known date of onset.
  2. Imaging evidence of definite or probable dissection on MRI/MRA, CTA or ultrasound.

Exclusion Criteria:

  1. Intracranial cerebral artery dissection
  2. Symptom onset after 7 days
  3. Contraindication to either antiplatelet agents or anticoagulation therapy
  4. Patient's refusal to consent
  5. Patients who are undergoing angiography and stenting or surgery for treatment of their dissection.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00238667

Locations
United Kingdom
St. George's University of London, Clinical Neuroscience Department, Cranmer Terrace Recruiting
London, England, United Kingdom, SW17 0RE
Contact: Dr. Ranjith K Menon, MRCP    0447786257463    rmenon@sgul.ac.uk   
Principal Investigator: Professor John W Norris, MD, FRCP         
Sponsors and Collaborators
St George's, University of London
The Stroke Association, United Kingdom
Investigators
Principal Investigator: Professor John W Norris, MD, FRCP St George's, University of London
Principal Investigator: Professor Hugh Markus, DM, FRCP St George's, University of London
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00238667     History of Changes
Other Study ID Numbers: CAMER5UA, 04/Q0803/113, 04.0287, 04/Q0803/15, 04/Q0803/215, TSA2004/16
Study First Received: October 11, 2005
Last Updated: October 16, 2006
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by St George's, University of London:
Extracranial carotid artery dissection
Dissection and stroke

Additional relevant MeSH terms:
Aneurysm, Dissecting
Stroke
Cerebral Infarction
Vertebral Artery Dissection
Aneurysm
Vascular Diseases
Cardiovascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Brain Infarction
Brain Ischemia
Cerebrovascular Trauma
Trauma, Nervous System
Wounds and Injuries

ClinicalTrials.gov processed this record on April 17, 2014