Estrogen and Perimenopausal Depression
The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2008 by University of California, Los Angeles.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
University of California, Los Angeles
Collaborator:
National Alliance for Research on Schizophrenia and Depression
Information provided by:
University of California, Los Angeles
ClinicalTrials.gov Identifier:
NCT00229450
First received: September 28, 2005
Last updated: June 2, 2008
Last verified: June 2008
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Purpose
During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough to warrant antidepressant medication. Whether or not women with perimenopausal depression respond to antidepressant medication may depend on the level of estrogen in their blood. We would like to investigate whether estrogen will help the women who only partially respond to antidepressant medications. We also want to examine how different doses of estrogen may affect individuals differently.
| Condition | Intervention | Phase |
|---|---|---|
|
Depressive Disorder, Major Menopause |
Drug: estrogen |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Single Blind Primary Purpose: Treatment |
| Official Title: | Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression |
Resource links provided by NLM:
Further study details as provided by University of California, Los Angeles:
Eligibility| Ages Eligible for Study: | 40 Years to 60 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Clinical Diagnosis of Unipolar Major Depression, currently taking antidepressants
- HAM-D between 10 and 17
Exclusion Criteria:
- History of Psychosis, breast cancer, smoking, dementia, clotting disorders
- Current substance abuse
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00229450
Contacts
| Contact: Melinda L. Morgan, Ph.D. | 310-825-5028 | melinda@ucla.edu |
Locations
| United States, California | |
| UCLA Neuropsychiatric Institute & Hospital | Recruiting |
| Los Angeles, California, United States, 90024 | |
| Contact: Jodie B. Cohen, B.S. 310-825-0528 jodie@mentalhealth.ucla.edu | |
| Sub-Investigator: Ian A. Cook, M.D. | |
| Sub-Investigator: Andrew F. Leuchter, M.D. | |
Sponsors and Collaborators
University of California, Los Angeles
National Alliance for Research on Schizophrenia and Depression
Investigators
| Principal Investigator: | Melinda L. Morgan, Ph.D. | University of California, Los Angeles |
More Information
Additional Information:
Publications:
| ClinicalTrials.gov Identifier: | NCT00229450 History of Changes |
| Other Study ID Numbers: | NARSAD06806-001, 06806-001, 04-05-088 |
| Study First Received: | September 28, 2005 |
| Last Updated: | June 2, 2008 |
| Health Authority: | United States: Federal Government |
Keywords provided by University of California, Los Angeles:
|
depression menopause perimenopause mood |
memory perimenopausal antidepressant estrogen |
Additional relevant MeSH terms:
|
Depression Depressive Disorder Depressive Disorder, Major Behavioral Symptoms Mood Disorders Mental Disorders |
Estrogens Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 16, 2013