The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation - Tabular View

Tracking Information
First Received Date ^ICMJE	September 21, 2005
Last Updated Date	April 9, 2007
Start Date ^ICMJE	September 2003
Primary Completion Date
Current Primary Outcome Measures ^ICMJE
Original Primary Outcome Measures ^ICMJE
Change History	Complete list of historical versions of study NCT00224926 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ^ICMJE
Original Secondary Outcome Measures ^ICMJE

Descriptive Information
Brief Title ^ICMJE	The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation
Official Title ^ICMJE	The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation
Brief Summary	To explore carrier and infection status of T.tonsurans tinea capitis and characterize the host-pathogen interaction as it relates to the disease presentation. The general hypothesis for this study is as follows: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.The global outcome of this investigation is to reveal potential new drug targets designed to improve treatment outcomes in these children.
Detailed Description	Tinea capitis is an overwhelmingly prevalent disease of childhood estimated to be present in approximately 1 in 20 children at any point in time with an equal number of children serving as carriers of the fungal pathogen. Despite the widespread nature of the disease, the natural course of the infection remains incompletely described. The study will be driven by the following hypothesis:the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection. A fungal scalp culture will be acquired from all participants using a brush culture technique. Samples will be collected once a month over a two year time period.
Study Phase
Study Type ^ICMJE	Observational
Study Design ^ICMJE	Natural History, Longitudinal, Random Sample
Condition ^ICMJE	Tinea Capitis
Intervention ^ICMJE	Procedure: Scalp Brushing
Study Arms / Comparison Groups
Publications *
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information
Recruitment Status ^ICMJE	Completed
Enrollment ^ICMJE	350
Completion Date	September 2005
Primary Completion Date
Eligibility Criteria ^ICMJE	Inclusion Criteria: Preschool aged children will be eligible. Exclusion Criteria: None
Gender	Both
Ages	2 Years to 5 Years
Accepts Healthy Volunteers	Yes
Contacts ^ICMJE	Contact information is only displayed when the study is recruiting subjects
Location Countries ^ICMJE	United States

Administrative Information
NCT ID ^ICMJE	NCT00224926
Responsible Party
Study ID Numbers ^ICMJE	PPRU 10704
Study Sponsor ^ICMJE	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborators ^ICMJE
Investigators ^ICMJE
Information Provided By	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Verification Date	April 2007
^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP