| Home | Search | Study Topics | Glossary |
|
|
|
 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsored by: |
National Institute of Child Health and Human Development (NICHD) |
| Information provided by: | National Institute of Child Health and Human Development (NICHD) |
| ClinicalTrials.gov Identifier: | NCT00224926 |
Purpose
To explore carrier and infection status of T.tonsurans tinea capitis and characterize the host-pathogen interaction as it relates to the disease presentation. The general hypothesis for this study is as follows: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.The global outcome of this investigation is to reveal potential new drug targets designed to improve treatment outcomes in these children.
| Condition | Intervention |
|
Tinea Capitis |
Procedure: Scalp Brushing |
| MedlinePlus related topics: | Tinea Infections |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Random Sample |
| Official Title: | The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation |
| Estimated Enrollment: | 350 |
| Study Start Date: | September 2003 |
| Estimated Study Completion Date: | September 2005 |
Tinea capitis is an overwhelmingly prevalent disease of childhood estimated to be present in approximately 1 in 20 children at any point in time with an equal number of children serving as carriers of the fungal pathogen. Despite the widespread nature of the disease, the natural course of the infection remains incompletely described. The study will be driven by the following hypothesis:the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.
A fungal scalp culture will be acquired from all participants using a brush culture technique. Samples will be collected once a month over a two year time period.
Eligibility
| Ages Eligible for Study: | 2 Years to 5 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations More Information
Pediatric Pharmacology Research Unit Website
|
| Study ID Numbers: | PPRU 10704 |
| First Received: | September 21, 2005 |
| Last Updated: | April 9, 2007 |
| ClinicalTrials.gov Identifier: | NCT00224926 |
| Health Authority: | United States: Federal Government |
|
|
|
|
|
