Clinical Study on Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain
Recruitment status was Recruiting
The project investigates on the role of pain avoidance, comorbidity and stress response for the development of chronic somatic and visceral pain. We, the researchers at University Hospital Mannheim, assume that implicit operant learning of pain sensitization is a central mechanism of the process of pain becoming chronic, which is augmented by fear and by avoidance behaviour. Somatic and psychological comorbidity as well as stress factors are further promoting factors in chronic pain development.
Irritable Bowel Syndrome
Behavioral: Experimental heat pain model
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Diagnostic
|Official Title:||Implicit Learning, Comorbidity and Stress Vulnerability in Chronic Functional Pain Syndromes|
|Study Start Date:||September 2005|
|Estimated Study Completion Date:||November 2007|
Study 1: Implicit operant learning of sensitization and habituation in an experimental heat pain model will be investigated and compared in healthy controls, chronic pain patients with fibromyalgia, with and w/o visceral pain.
Study 2: Functional imaging of implicit operant learning of sensitization and habituation in an experimental heat pain model (same subgroups as in study 1).
|Contact: Ulrike Kiessling, Dr. phil.||+49 621 181 firstname.lastname@example.org|
|University of Mannheim - Otto-Selz-Institute||Recruiting|
|Mannheim, Germany, D-68131|
|Contact: Dieter Kleinboehl, Dr. phil. +49 621 181 2111 email@example.com|
|Study Director:||Rupert Hoelzl, Prof. Dr. phil.||University of Mannheim|
|Study Director:||Hans-Joachim Bender, Prof. Dr. med. rer. nat.||University Hospital Mannheim|
|Study Director:||Lothar-Rudi Schad, Prof. Dr. rer. nat.||German Cancer Research Centre Heidelberg|