High-Intensity Exercise Training in Patients With Post-Infarction Heart Failure

This study has been completed.
Sponsor:
Information provided by:
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00218933
First received: September 20, 2005
Last updated: October 23, 2008
Last verified: August 2008
  Purpose

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. However attenuation of left ventricular (LV) remodelling has been documented in some studies. The effects of high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study.

Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.


Condition Intervention Phase
Heart Failure
Myocardial Infarction
Exercise Training
Behavioral: Exercise training
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Anti-Remodeling Effect of High-Intensity Interval Training in Patients With Post-Infarction Heart Failure on Optimal Treatment

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Remodelling of heart function and structure

Secondary Outcome Measures:
  • Improved endothelial and skeletal muscle as well as quality of life

Estimated Enrollment: 27
Study Start Date: October 2001
Estimated Study Completion Date: September 2005
  Eligibility

Ages Eligible for Study:   30 Years and older
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

Post-infarction heart failure and optimal treatment (ACE-inhibitors, Beta-blockade)

Exclusion Criteria:

Not able to walk on a treadmill, unstable angina, participating in another experiment, serious arrhythmia

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00218933

Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00218933     History of Changes
Other Study ID Numbers: HFEX-1
Study First Received: September 20, 2005
Last Updated: October 23, 2008
Health Authority: Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:
Interval training
Endothelial dysfunction
Aerobic capacity

Additional relevant MeSH terms:
Heart Failure
Infarction
Myocardial Infarction
Heart Diseases
Cardiovascular Diseases
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Vascular Diseases

ClinicalTrials.gov processed this record on October 01, 2014