Divalproex Sodium (Depakote) for Explosive Tempers in Adolescents and Adults
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Purpose
The purpose of this study is to compare the effectiveness of divalproex sodium (Depakote) versus placebo in treating disruptive behavior disorder and explosive tempers in adolescents and adults.
| Condition | Intervention | Phase |
|---|---|---|
|
Attention Deficit and Disruptive Behavior Disorders Marijuana Abuse |
Drug: Divalproex Sodium (Depakote) Drug: divalproex sodium |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment |
| Official Title: | Parallel Groups Study of Divalproex Sodium (Depakote) for Irritable, Explosive Adults & Adolescents |
- Symptoms of disruptive behavior disorder (measured throughout the study and at Week 6) [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 75 |
| Study Start Date: | February 2000 |
| Estimated Study Completion Date: | January 2014 |
| Estimated Primary Completion Date: | January 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Divalproex sodium (Depakote)
|
Drug: Divalproex Sodium (Depakote)
Subjects are titrated over 2 weeks, as tolerated to 10 mgs / pound, and blood levels are checked to determine that the blood level is between 50-110 micrograms / ml
Drug: divalproex sodium
divalproex sodium in 250 mgs doses titrated to 10 mgs /lb to reach a blood level between 50-110 micrograms/ml
|
|
Placebo Comparator: 2
matching placebo for 250 mgs divalproex sodium
|
Drug: divalproex sodium
divalproex sodium in 250 mgs doses titrated to 10 mgs /lb to reach a blood level between 50-110 micrograms/ml
|
Detailed Description:
Disruptive behavior disorders among children and adolescents are readily diagnosed; however, few individuals with such disorders receive drug treatment. Depakote is a mood stabilizing medication that may be beneficial in treating individuals with disruptive behavior disorders. The purpose of this study is to examine the effectiveness of Depakote in reducing temper outbursts and improving mood in individuals with disruptive behavior disorders. In addition, this study will determine the safety and effectiveness of Depakote in treating individuals with substance disorders who also have disruptive behavior disorders.
This study will last 6 weeks. Participants will be randomly assigned to receive treatment with Depakote or placebo. Medication will be given in a single evening dose if tolerated; otherwise, medication will be given twice per day. Participants will be assigned to a fixed-flexible dosing schedule and dosages will increase based on weight. All participants will attend weekly psychotherapy and family counseling sessions throughout the study. Participants who are substance abusers will also receive substance abuse counseling. Weekly study visits will include a physical exam, blood collection, and drug tests. Teachers and guidance counselors will be contacted to assess the participant's behavior from week to week. Some participants will complete a follow-up study, in which they will take part in phone interviews.
Eligibility| Ages Eligible for Study: | 12 Years to 55 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Meets DSM-IV criteria for a disruptive behavior disorder (e.g., oppositional/defiant disorder, conduct disorder)
- Explosive temper, defined as four or more outbursts of rage, property destruction, or fighting per month
- Mood liability, defined as having multiple, daily, distinct shifts from normal to irritable mood with withdrawn or boisterous behavior
- Chronic symptoms, defined of at least 1 year duration when not receiving treatment
- Impairment from the above symptoms in two or more areas, including school, the law, family, substance use, peers, or work (as manifested by a GAF score of 55 or less)
- Symptoms not limited to a particular place or to particular intimate relationships
- General good health
- Custodial parent or guardian gives informed consent
Exclusion Criteria:
- History of non drug-induced psychosis
- Seizure or other neurologic disturbance
- Pregnant
- Moderate to severe mental retardation
- Sexually active females who refuse to use an adequate method of contraception for the duration of the study
- Significant medical problems
- Current suicidal or homicidal ideation
- Uses barbiturates
- Refusal to permit weekly contact with school officials
- Bipolar I or II disorder
- Major depressive disorder
- First degree relative with bipolar I or II disorder
- Attention deficit/hyperactivity disorder
- Post traumatic stress disorder
- Clinical evidence of hyperandrogenism in a female
- Liver disease
- Thrombocytopenia
- Pancreatic disease
Contacts and Locations| United States, New York | |
| New York State Psychiatric Institute | |
| New York, New York, United States, 10032 | |
| Principal Investigator: | Stephen Donovan, MD | New York State Psychiatric Institute |
More Information
No publications provided
| Responsible Party: | New York State Psychiatric Institute |
| ClinicalTrials.gov Identifier: | NCT00218114 History of Changes |
| Other Study ID Numbers: | #4767R, R01DA012234, DPMC |
| Study First Received: | September 16, 2005 |
| Last Updated: | December 13, 2012 |
| Health Authority: | United States: Federal Government |
Additional relevant MeSH terms:
|
Mental Disorders Attention Deficit and Disruptive Behavior Disorders Marijuana Abuse Attention Deficit Disorder with Hyperactivity Mental Disorders Diagnosed in Childhood Substance-Related Disorders Valproic Acid Anticonvulsants Central Nervous System Agents Therapeutic Uses |
Pharmacologic Actions Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action GABA Agents Neurotransmitter Agents Physiological Effects of Drugs Antimanic Agents Tranquilizing Agents Central Nervous System Depressants Psychotropic Drugs |
ClinicalTrials.gov processed this record on June 17, 2013