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Effect of Yohimbine on Colon Transit
This study has been completed.
Study NCT00217048   Information provided by Mayo Clinic
First Received: September 16, 2005   Last Updated: April 27, 2009   History of Changes

September 16, 2005
April 27, 2009
June 2005
October 2005   (final data collection date for primary outcome measure)
Colonic transit
Same as current
Complete list of historical versions of study NCT00217048 on ClinicalTrials.gov Archive Site
  • Small bowel transit time
  • Gastric emptying time
  • Maximum tolerated volume ingested during satiation testing
  • Average stools per day
  • Stool consistency
Same as current
 
Effect of Yohimbine on Colon Transit
Effect of Oral Yohimbine on Colonic Transit: Randomized, Placebo-Controlled Trial

This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.

 
Phase I, Phase II
Interventional
Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Healthy Volunteers
Drug: Yohimbine, oral
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
30
October 2005
October 2005   (final data collection date for primary outcome measure)
  • Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old;
  • Able to provide written informed consent before participating in the study;
  • Able to communicate adequately with the investigator and to comply with the requirements for the entire study.
Both
18 Years to 65 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00217048
 
275-05
Mayo Clinic
National Institutes of Health (NIH)
Principal Investigator: Adil E Bharucha, MBBS, M.D. Mayo Clinic
Mayo Clinic
April 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP