Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer
This study has been completed.
Sponsor:
Hoosier Oncology Group
Collaborators:
Novartis Pharmaceuticals
Sanofi
Walther Cancer Institute
Information provided by:
Hoosier Oncology Group
ClinicalTrials.gov Identifier:
NCT00216112
First received: September 12, 2005
Last updated: April 28, 2011
Last verified: April 2011
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Purpose
Imatinib mesylate is an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events. Docetaxel promotes cell growth arrest by inhibiting the deassembly of tubulin and by promoting at the same time microtubule assembly. Docetaxel has single agent activity in ovarian cancer with response rates of 30-40% in the platinum refractory setting. The combination of imatinib mesylate and docetaxel has potential synergistic effects, based on previous reports showing synergy in-vitro and in-vivo between PDGFR inhibitors or PI3K inhibitors and taxane chemotherapy.
This trial will investigate the efficacy the combination of imatinib mesylate and docetaxel in treating patients with advanced, platinum-refractory ovarian cancer and primary peritoneal carcinomatosis.
| Condition | Intervention | Phase |
|---|---|---|
|
Ovarian Cancer |
Drug: Imatinib Mesylate Drug: Docetaxel |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Imatinib Mesylate (Gleevec®, STI571) in Combination With Docetaxel (Taxotere) for the Treatment of Advanced, Platinum-Refractory Ovarian Cancer and Primary Peritoneal Carcinomatosis: Hoosier Oncology Group GYN03-62 |
Resource links provided by NLM:
Further study details as provided by Hoosier Oncology Group:
Primary Outcome Measures:
- · To determine response rate (CR, PR and SD) of patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit receiving imatinib mesylate in combination with docetaxel. [ Time Frame: 24 months ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- · To assess the safety and tolerability of imatinib mesylate in combination with docetaxel in patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit. [ Time Frame: 24 months ] [ Designated as safety issue: Yes ]
- · To determine progression free survival and overall survival in patients with advanced, platinum-refractory ovarian cancer, whose tumors over-express PDGFR or c-kit, receiving imatinib mesylate in combination with docetaxel. [ Time Frame: 24 months ] [ Designated as safety issue: No ]
- · To determine whether basal level of Akt expression or Akt activation (phospho-Akt) in ovarian tumors impacts response to treatment with imatinib and docetaxel. [ Time Frame: 24 months ] [ Designated as safety issue: No ]
| Enrollment: | 23 |
| Study Start Date: | December 2003 |
| Study Completion Date: | July 2007 |
| Primary Completion Date: | October 2005 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: 1
Imatinib + docetaxel
|
Drug: Imatinib Mesylate
Imatinib mesylate 600 mg po qd
Drug: Docetaxel
Docetaxel 30 mg/m2 (4 of 6 weeks); 1 cycle = 6 weeks
|
Detailed Description:
OUTLINE: This is a multi-center study.
Submit tumor and serum samples for central review
- Imatinib 600 mg (orally qd);
- Docetaxel 30mg/m2 (4 of 6 weeks);1 cycle = 6 weeks
- Evaluate every other cycle
Each cycle will begin only when the granulocyte count is > 1,500/mm3 and the platelet count is > 100,000/mm3 and any other treatment-related toxicities are < grade 1. If the toxicity is not resolved to grade 0 or 1 after three weeks, the patient will be withdrawn from the study. For days 8, 15, and 22 patients must have an absolute neutrophil count > 1,000/mm3 or greater and platelet count > 75,000/mm3. Imatinib mesylate can be administered if platelets >20,000 and ANC >500.
ECOG performance status 0 or 1
Hematopoietic:·
- ANC > 1,500/mm3·
- Platelets > 100,000 mm3·
- Hgb > 8g/dl
Hepatic:·
- Albumin>3gm/dL·
- Total bilirubin < ULN·
- Maximum Alk Phos: >2.5x but < 5x ULN
Renal:·
- Creatinine < 1.5 x ULN·(by Cockroft and Gault)
Cardiovascular:·
- No grade III/IV cardiac problems as defined by the New York Heart Association Criteria. (i.e., congestive heart failure, myocardial infarction within 6 months prior to beginning protocol therapy)
Pulmonary:·
- Not specified
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Histologically documented diagnosis of ovarian cancer, primary peritoneal carcinomatosis or fallopian tube cancer·
- Immunohistochemical documentation of c-Kit or PDGFR expression by tumor
- At least one measurable site of disease as defined by RECIST or evidence of disease progression by CA125 measurement
- Platinum-refractory or platinum-resistant
Exclusion Criteria:
- No prior exposure to imatinib (Gleevec®) as single agent or in combination
- No chemotherapy within 28 days (42 days for nitrosourea or mitomycin-C) prior to being registered to protocol therapy.
- No prior radiotherapy to ³ 25 % of the bone marrow
- No known brain metastases.
- Negative pregnancy test
- No current breastfeeding
- No investigational agents within 28 days prior to protocol therapy
- No prior malignancy in the past 5 years unless the other primary malignancy is not currently clinically significant, nor requiring active intervention, or if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ
- No severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection)
- No known diagnosis of human immunodeficiency virus (HIV) infection.
- No major surgery within 28 days prior to being registered to protocol therapy.
- No refractory ascites requiring drainage more frequently than once a month
- No presence of clinically significant small bowel obstruction
- No prior exposure to docetaxel (exposure to paclitaxel is allowed)
- No parenteral nutrition within 28 days prior to being registered to protocol therapy.
- No concomitant treatment with potent CYP 3A4 inhibitors (i.e., ketoconazole) is permitted during therapy on this protocol.
- No therapeutic anticoagulation with warfarin while on study (use of low molecular weight heparin is allowed, if necessary).
- No peripheral neuropathy > grade 1
- No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80.
- No serious concomitant systemic disorders incompatible with the study
- No prior malignancies with the exception of curatively treated basal or squamous carcinoma of the skin, carcinoma in-situ of the cervix, or any other cancer for which the patient has been disease-free for < 5 years.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00216112
Locations
| United States, Illinois | |
| Medical & Surgical Specialists, LLC | |
| Galesburg, Illinois, United States, 61401 | |
| United States, Indiana | |
| Elkhart Clinic | |
| Elkhart, Indiana, United States, 46515 | |
| Oncology Hematology Associates of SW Indiana | |
| Evansville, Indiana, United States, 47714 | |
| Fort Wayne Oncology & Hematology, Inc | |
| Fort Wayne, Indiana, United States, 46815 | |
| Indiana University Cancer Center | |
| Indianapolis, Indiana, United States, 46202 | |
| Arnett Cancer Care | |
| Lafayette, Indiana, United States, 47904 | |
| Medical Consultants, P.C. | |
| Muncie, Indiana, United States, 47303 | |
| Center for Cancer Care, Inc., P.C. | |
| New Albany, Indiana, United States, 47150 | |
| AP&S Clinic | |
| Terre Haute, Indiana, United States, 47804 | |
Sponsors and Collaborators
Hoosier Oncology Group
Novartis Pharmaceuticals
Sanofi
Walther Cancer Institute
Investigators
| Study Chair: | Daniela Matei, M.D. | Hoosier Oncology Group, LLC |
More Information
Additional Information:
Publications:
| Responsible Party: | Daniela Matei, M.D., Hoosier Oncology Group |
| ClinicalTrials.gov Identifier: | NCT00216112 History of Changes |
| Other Study ID Numbers: | HOG GYN 03-62 |
| Study First Received: | September 12, 2005 |
| Last Updated: | April 28, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Hoosier Oncology Group:
|
Ovarian Cancer |
Additional relevant MeSH terms:
|
Ovarian Neoplasms Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Ovarian Diseases Adnexal Diseases Genital Diseases, Female Genital Neoplasms, Female Urogenital Neoplasms Endocrine System Diseases |
Gonadal Disorders Docetaxel Imatinib Antineoplastic Agents Therapeutic Uses Pharmacologic Actions Protein Kinase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |
ClinicalTrials.gov processed this record on May 19, 2013