COAST (Childhood Origins of ASThma)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Information provided by (Responsible Party):
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT00204841
First received: September 12, 2005
Last updated: May 31, 2013
Last verified: May 2013
  Purpose

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.


Condition
Asthma
Allergy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cytokine Dysregulation, Virus Infection, and Asthma: The Pathogenesis of Childhood Asthma

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines


Estimated Enrollment: 300
Study Start Date: October 1998
Estimated Study Completion Date: May 2018
Estimated Primary Completion Date: May 2018 (Final data collection date for primary outcome measure)
Detailed Description:

No more description necessary.

  Eligibility

Ages Eligible for Study:   up to 2 Minutes
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

High risk birth cohort of children (one or both parents have allergies and/or asthma).

Criteria

Inclusion Criteria:

  • children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

  • pre term infants
  • low birth weight infants
  • respiratory distress at birth
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00204841

Locations
United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Robert F Lemanske, Jr., MD University of Wisconsin, Madison
  More Information

Additional Information:
No publications provided

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT00204841     History of Changes
Other Study ID Numbers: 1998-129, 5P01HL070831-08
Study First Received: September 12, 2005
Last Updated: May 31, 2013
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on July 24, 2014