COAST (Childhood Origins of ASThma)
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Cytokine Dysregulation, Virus Infection, and Asthma: The Pathogenesis of Childhood Asthma|
- Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines
|Study Start Date:||October 1998|
|Estimated Study Completion Date:||May 2018|
|Estimated Primary Completion Date:||May 2018 (Final data collection date for primary outcome measure)|
No more description necessary.
|United States, Wisconsin|
|University of Wisconsin|
|Madison, Wisconsin, United States, 53792|
|Principal Investigator:||Robert F Lemanske, Jr., MD||University of Wisconsin, Madison|