The Effect of 0.5% Roxithromycin Lotion for Androgenetic Alopecia
Recruitment status was Active, not recruiting
The purpose of this study is exploiting the new drugs for androgenetic alopecia because there are still no effective and safe topical drug for androgenetic alopecia. Roxithomycin is one of the macrolide antibiotics that has immunomodulatory effects. We firstly found that roxithromycin increases the rate of murine and human hair follicle elongation in vitro. Therefore, we apply this drug on this disease therapy.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Study for New Effect of Roxithromycin on Androgenetic Alopecia.|
- Pathological study taken from lesional scalp skin. [ Time Frame: One year ]
|Study Start Date:||May 2005|
|Estimated Study Completion Date:||January 2007|
The topical therapy for androgenetic alopecia is still not enough to improve cosmetically. Thereforem we try to find new effective and safe topical therapy for this disease. Roxithromycin has not only antibacterial action but also immunomodulatory and anti-inflamatory potency. For example, roxitromycin inhibits T cell responces to mitogens and production of cytokines, IL-2 and IL-5. We firstly found that roxitromycin increased human and murine hair elongation in vitro to inhibit apoptosis of hair bulb. Then, we wish to apply roxithromycin on the therapy for androgenetic alopecia.
|Department of Dermatology, Hamamatsu University School of Medicine|
|Hamamatsu, Japan, 431-3192|
|Study Chair:||Masahiro Takigawa, M.D.||Hamamatsu University|