Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by Weill Medical College of Cornell University.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Information provided by:
Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:
NCT00195052
First received: September 14, 2005
Last updated: September 21, 2010
Last verified: September 2010
  Purpose

Epilepsy is a disease affecting 1-2% of the population. Currently, the only known cure for epilepsy is surgery, which is much more effective at eliminating seizures arising from the medial temporal lobe compared with the neocortex. The problem with neocortical epilepsy is that the population of neurons underlying each epileptiform discharge varies over time. In addition, the spatial relationship between interictal events and the ictal onset zones, which are critical in defining the region of epileptogenesis, is not well understood and essential to the surgical treatment of epilepsy. Electrophysiological recording methods, although currently the "gold standard" in mapping epilepsy, are inadequate to address these questions based on restrictions due to volume conduction or sampling limitations. Optical recording techniques can overcome many of these limitations by sampling large areas of cortex simultaneously to provide information about blood flow, metabolism and extracellular fluid shifts that are intimately related to excitatory and inhibitory neuronal activity. In fact, optical recordings may actually be more sensitive to certain aspects of epileptic activity than electrophysiologic recordings. The goal will be to translate these findings into the operating room and map human neocortical epilepsy with the same optical techniques. Outcome following surgical resections to treat neocortical epilepsy will be correlated with the optical maps to determine the utility of intrinsic signal imaging in guiding brain surgery. These experiments will set the groundwork for implementing optical recordings in general clinical practice as a novel technique for mapping and predicting human seizures.


Condition
Epilepsy

Study Type: Observational
Study Design: Observational Model: Case-Only
Official Title: Intraoperative Optical Imaging Mapping of Neocortical Epilepsy in Human

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Further study details as provided by Weill Medical College of Cornell University:

Estimated Enrollment: 40
Study Start Date: May 2002
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The patient, who is going to undergo a neurosurigcal procedure which will require intraoperative brain mapping to determine the brain organization, is the potential study subject.

Criteria

Inclusion Criteria:

  • patients with medically intractable epilepsy, between 18-65 ages

Exclusion Criteria:

-

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00195052

Contacts
Contact: Theodore H Schwartz, MD 212-746-5620 schwarh@med.cornell.edu
Contact: Hongtao Ma, Ph.D. 212-746-5516 hom2001@med.cornell.edu

Locations
United States, New York
Weill Cornell Medical College/New York Presbyterian Hospital Recruiting
New York, New York, United States, 10021
Sponsors and Collaborators
Weill Medical College of Cornell University
Investigators
Principal Investigator: Theodore H Schwartz, MD Weill Cornell Medical College/New York Presbyterian Hospital
  More Information

No publications provided

Responsible Party: Theodore H. Schwartz, The Newyork-Presbyterian hospital-Weill Cornell Medical College of Cornell University
ClinicalTrials.gov Identifier: NCT00195052     History of Changes
Other Study ID Numbers: 0102004808
Study First Received: September 14, 2005
Last Updated: September 21, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Epilepsy
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on September 30, 2014