Dutch Prediction of Psychosis Study

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by UMC Utrecht.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborators:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
UMC Utrecht
ClinicalTrials.gov Identifier:
NCT00188981
First received: September 9, 2005
Last updated: April 19, 2007
Last verified: April 2007
  Purpose

The Dutch Prediction of Psychosis Study (DUPS) is a prospective study of predictors of the transition to psychosis in help-seeking adolescents at high risk for developing a first psychotic episode. The aim of the project is supplemented by a systematic account of the pathways to care, the disabilities and needs and the therapeutic interventions that are currently used in this population.

Multi-level assessment includes behavioral and cognitive variables as well as structural brain imaging and neurophysiological data. Subjects will be followed up at regular intervals during (at least) two years to monitor the development of their (psychotic) symptoms. This will allow us to analyze the predictive validity of the variables.


Condition
Psychotic Disorders

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: Dutch Prediction of Psychosis Study

Resource links provided by NLM:


Further study details as provided by UMC Utrecht:

Estimated Enrollment: 120
Study Start Date: June 2003
Estimated Study Completion Date: June 2008
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   12 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria:

Help-seeking adolescents who belong to one or more of the following groups:

  • Basic symptoms: presence of self-perceived cognitive thought disturbances
  • Familial risk plus reduced functioning: having a first- or second degree relative with a history of any psychotic disorder in combination with a deterioration of mental state and/or social functioning in the last year
  • Attenuated psychotic symptoms: presence of psychotic symptoms at sub-clinical level
  • Brief, limited or intermittent psychotic symptoms: having a history of psychotic symptoms with a duration of less than one week and spontaneous remission
  • Multiple Complex Developmental disorder

Exclusion criteria:

  • A previous psychotic episode for more than one week
  • Verbal IQ < 75
  • Symptoms are due to an organic mental disorder or substance abuse
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00188981

Locations
Netherlands
University Medical Center Utrecht, department of Child and Adolescent Psychiatry
Utrecht, Netherlands
Sponsors and Collaborators
UMC Utrecht
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ZonMw: The Netherlands Organisation for Health Research and Development
Investigators
Principal Investigator: Patricia Schothorst, PhD University Medical Center Utrecht, department of Child and Adolescent Psychiatry
Principal Investigator: Herman van Engeland, Professor University Medical Center Utrecht, department of Child and Adolescent Psychiatry
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00188981     History of Changes
Other Study ID Numbers: CCMOP02.0441C, METC02/178
Study First Received: September 9, 2005
Last Updated: April 19, 2007
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by UMC Utrecht:
psychosis
high risk
prodrome
Multiple Complex Developmental Disorder

Additional relevant MeSH terms:
Psychotic Disorders
Mental Disorders
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on September 22, 2014