Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by University Health Network, Toronto.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Health Network, Toronto
ClinicalTrials.gov Identifier:
NCT00188890
First received: September 12, 2005
Last updated: January 19, 2012
Last verified: January 2012
  Purpose

Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.


Condition
Lung Cancer
Mesothelioma

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-dose Computed Tomography

Resource links provided by NLM:


Further study details as provided by University Health Network, Toronto:

Estimated Enrollment: 1000
Study Start Date: March 2005
Estimated Study Completion Date: March 2013
Groups/Cohorts
1
prior exposure to asbestos

  Eligibility

Ages Eligible for Study:   30 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

prior exposure to asbestos and or documented pleural plaques

Criteria

Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00188890

Contacts
Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583 demetris.patsios@uhn.on.ca
Contact: Brenda O'Sullivan 416-340-4800 ext 5686 Brenda.O'Sullivan@uhn.on.ca

Locations
Canada, Ontario
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada
Contact: Demetris Patsios, MD    Tel: (416) 603-5800 ext 2583    demetris.patsios@uhn.on.ca   
Contact: Brenda O'Sullivan, MD    416-340-4800 ext 5686    brenda.o'sullivan@uhn.on.ca   
Sponsors and Collaborators
University Health Network, Toronto
Investigators
Principal Investigator: Demetris Patsios, MD University Health Network, Toronto
Principal Investigator: Marc de Perrot, MD University Health Network, Toronto
  More Information

No publications provided

Responsible Party: Demetris Patsios, MD, UHN
ClinicalTrials.gov Identifier: NCT00188890     History of Changes
Other Study ID Numbers: Asbestos Screening Study
Study First Received: September 12, 2005
Last Updated: January 19, 2012
Health Authority: Canada: Health Canada

Keywords provided by University Health Network, Toronto:
Lung Cancer
Mesothelioma
Asbestos
Screening
Early Diagnosis

Additional relevant MeSH terms:
Mesothelioma
Lung Neoplasms
Neoplasms, Mesothelial
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Adenoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on September 18, 2014