Effect of Genetic Variants in the Xenobiotic Transporter, OCT1, on Response to Metformin in Healthy Subjects

This study is currently recruiting participants.

Verified by University of California, San Francisco, September 2005

First Received: September 13, 2005 No Changes Posted

Sponsor:	University of California, San Francisco
Information provided by:	University of California, San Francisco
ClinicalTrials.gov Identifier:	NCT00187681

Purpose

Specific Objectives:

To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who carry the common allele.
To determine if individuals who carry the decreased or non-functional variants exhibit differences in the response to metformin in comparison to individuals who carry the common allele.

Condition	Intervention
Healthy Volunteer	Drug: Metformin HCl

Study Type:	Interventional
Study Design:	Diagnostic, Non-Randomized, Open Label, Uncontrolled, Parallel Assignment, Pharmacokinetics/Dynamics Study

Resource links provided by NLM:

Drug Information available for: Metformin Metformin hydrochloride

Eligibility

Criteria

Inclusion Criteria:

Exclusion Criteria:

Taking any medications other than vitamins
Individuals with anemia (hemoglobin < 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL)
Pregnant at time of study.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00187681

Contacts

Contact: Chaline Brown, PharmD

415-476-6756

Locations

United States, California
San Francisco General Hospital	Recruiting
San Francsico, California, United States, 94143
Contact: Chaline Brown, PharmD 415-476-6756 brownc@pharmacy.ucsf.edu

Sponsors and Collaborators

University of California, San Francisco

Investigators

Principal Investigator:

Kathleen M Giacomini, PhD

University of California, San Francisco

More Information

No publications provided

Study ID Numbers:	865
Study First Received:	September 13, 2005
Last Updated:	September 13, 2005
ClinicalTrials.gov Identifier:	NCT00187681 History of Changes
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Hypoglycemic Agents
Physiological Effects of Drugs
Metformin
Pharmacologic Actions

ClinicalTrials.gov processed this record on November 30, 2009