Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)
Collect DNA from well-characterized healthy volunteers.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)|
- Healthy Control [ Time Frame: On-going ] [ Designated as safety issue: No ]Amass a cohort of healthy controls to be used for future genotype to phenotype studies.
Biospecimen Retention: Samples With DNA
40 mL of blood for DNA extraction
|Study Start Date:||February 2004|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
DNA and plasma will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations.
Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00187668
|United States, California|
|San Francisco General Hopsital CTSI CRC||Recruiting|
|San Francisco, California, United States, 94143|
|Contact: Hector Vizoso, RN-BC, MSN 415-206-3317 firstname.lastname@example.org|
|Principal Investigator:||Kathleen M Giacomini, PhD||University of California, San Francisco|