How Smoking Causes COPD: Examination of Immune System Changes
A breathing condition known as "chronic obstructive pulmonary disease" (COPD) caused by cigarette smoking is a major health problem. The way by which smoking leads to lung disease is uncertain. Recent research done in animals provides a description of specific changes (that is a reduction) in these immune cell types as a result of cigarette smoke exposure. The study you have been asked to participate in is a pilot study to see if similar changes occur in humans who smoke. The purpose of this study is to evaluate this new method of testing blood in 3 groups of 10 people: normal non-smoking subjects, subjects who smoke with no history of lung disease and subjects who smoke and have smoking related COPD.
Chronic Obstructive Pulmonary Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||How Smoking Causes COPD: Examination of Immune System Changes|
|Study Start Date:||May 2005|
|Estimated Study Completion Date:||April 2012|
The mechanism by which smoking leads to damage to lung tissue in susceptible hosts, is uncertain. Recently there has been description of specific changes (that is reduction) in the number and activity of certain key immune cell types - dendritic cells- as a result of cigarette smoke exposure. This work was done in animal models and we would like to develop methods that will allow us to examine if similar changes occur in humans who smoke. Reduced number and activity of dendritic cells would be expected to lead to increased incidence of infection - a common problem in patients with COPD.
Since dendritic cells come to the lung from the bloodstream, and one can detect them in the circulation, we will look at the dendritic cells that are present in the peripheral blood.
|Contact: Susan E Carruthers, MLT||905-522-1155 ext email@example.com|
|Contact: Sarah E Goodwin, BA RRT CCRC||905-522-1155 ext firstname.lastname@example.org|
|St Joseph's Healthcare||Recruiting|
|Hamilton, Ontario, Canada, L8N 4A6|
|Contact: Gerard Cox, MB FRCPC FRCPI 905-522-1155 ext 5039 email@example.com|
|Contact: Martin Stampfli, PhD 905-525-9140 ext 22473 firstname.lastname@example.org|
|Principal Investigator: Gerard Cox, MB FRCPC FRCPI|
|Sub-Investigator: Martin Stampfli, PhD|
|Principal Investigator:||Gerard Cox, MB FRCPC FRCPI||McMaster University|