How Smoking Causes COPD: Examination of Immune System Changes

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by St. Joseph's Healthcare Hamilton.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
St. Joseph's Healthcare Hamilton
ClinicalTrials.gov Identifier:
NCT00186719
First received: September 13, 2005
Last updated: July 25, 2011
Last verified: July 2011
  Purpose

A breathing condition known as "chronic obstructive pulmonary disease" (COPD) caused by cigarette smoking is a major health problem. The way by which smoking leads to lung disease is uncertain. Recent research done in animals provides a description of specific changes (that is a reduction) in these immune cell types as a result of cigarette smoke exposure. The study you have been asked to participate in is a pilot study to see if similar changes occur in humans who smoke. The purpose of this study is to evaluate this new method of testing blood in 3 groups of 10 people: normal non-smoking subjects, subjects who smoke with no history of lung disease and subjects who smoke and have smoking related COPD.


Condition
Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: How Smoking Causes COPD: Examination of Immune System Changes

Resource links provided by NLM:


Further study details as provided by St. Joseph's Healthcare Hamilton:

Estimated Enrollment: 100
Study Start Date: May 2005
Estimated Study Completion Date: April 2012
Detailed Description:

The mechanism by which smoking leads to damage to lung tissue in susceptible hosts, is uncertain. Recently there has been description of specific changes (that is reduction) in the number and activity of certain key immune cell types - dendritic cells- as a result of cigarette smoke exposure. This work was done in animal models and we would like to develop methods that will allow us to examine if similar changes occur in humans who smoke. Reduced number and activity of dendritic cells would be expected to lead to increased incidence of infection - a common problem in patients with COPD.

Since dendritic cells come to the lung from the bloodstream, and one can detect them in the circulation, we will look at the dendritic cells that are present in the peripheral blood.

  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

smokers and non-smokers

Criteria

Inclusion Criteria:

  • Age > 40 years
  • Healthy Subjects - Non smokers
  • FEV1/FVC > 70% predicted
  • Current Smokers - > 10 pack year smoking history
  • FEV1/FVC > 70% predicted
  • Current Smokers with COPD - > 10 pack year smoking history
  • FEV1/FVC < 70% predicted
  • Able to give informed consent

Exclusion Criteria:

  • Healthy Subjects - Reside with smokers
  • History of lung disease
  • Current Smokers - History of lung disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00186719

Contacts
Contact: Susan E Carruthers, MLT 905-522-1155 ext 2208 scarruth@stjosham.on.ca
Contact: Sarah E Goodwin, BA RRT CCRC 905-522-1155 ext 6130 sgoodwin@stjosham.on.ca

Locations
Canada, Ontario
St Joseph's Healthcare Recruiting
Hamilton, Ontario, Canada, L8N 4A6
Contact: Gerard Cox, MB FRCPC FRCPI    905-522-1155 ext 5039    coxp@mcmaster.ca   
Contact: Martin Stampfli, PhD    905-525-9140 ext 22473    stampfli@mcmaster.ca   
Principal Investigator: Gerard Cox, MB FRCPC FRCPI         
Sub-Investigator: Martin Stampfli, PhD         
Sponsors and Collaborators
St. Joseph's Healthcare Hamilton
Investigators
Principal Investigator: Gerard Cox, MB FRCPC FRCPI McMaster University
  More Information

No publications provided

Responsible Party: Dr. Gerard Cox, St. Joseph's Healthcare Hamilton
ClinicalTrials.gov Identifier: NCT00186719     History of Changes
Other Study ID Numbers: 02-2182
Study First Received: September 13, 2005
Last Updated: July 25, 2011
Health Authority: Canada: Health Canada

Keywords provided by St. Joseph's Healthcare Hamilton:
Chronic Obstructive Pulmonary Disease
Smoking Related Disease
Immune System Changes

Additional relevant MeSH terms:
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Smoking
Lung Diseases, Obstructive
Respiratory Tract Diseases
Habits

ClinicalTrials.gov processed this record on April 20, 2014