Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

This study has been completed.
Sponsor:
Collaborator:
Aarhus University Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00184444
First received: September 15, 2005
Last updated: November 16, 2011
Last verified: November 2011
  Purpose

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured.

The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.


Condition Intervention
Angina Pectoris
Behavioral: Hypoxic interval training
Behavioral: Normoxic interval training

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • maximal oxygen uptake [ Time Frame: Baseline and post training ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Cardiac perfusion [ Time Frame: Baseline and post training ] [ Designated as safety issue: No ]
  • work economy [ Time Frame: Baseline and post training ] [ Designated as safety issue: No ]
  • cardiac output [ Time Frame: baseline and post training ] [ Designated as safety issue: No ]

Enrollment: 25
Study Start Date: September 2004
Study Completion Date: July 2007
Primary Completion Date: July 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Hypoxic Interval training
4 x 4 minutes interval training with 100% oxygenated air
Behavioral: Hypoxic interval training
4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max
Experimental: Normoxic interval training
4 x 4 minutes interval training in normoxic air
Behavioral: Normoxic interval training
4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • stable angina pectoris age 18-75

Exclusion Criteria:

  • unstable angina pectoris
  • Limitations to exercise other than coronary artery disease
  • Participants in other study interventions
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00184444

Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Aarhus University Hospital
Investigators
Study Director: Asbjørn Støylen, MD Norwegian university of sience and technology
  More Information

No publications provided

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00184444     History of Changes
Other Study ID Numbers: 094-2004
Study First Received: September 15, 2005
Last Updated: November 16, 2011
Health Authority: Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:
angina pectoris
hyperoxia
endurance training
stroke volume
cardiac perfusion

Additional relevant MeSH terms:
Angina Pectoris
Angina, Stable
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Chest Pain
Pain
Signs and Symptoms

ClinicalTrials.gov processed this record on October 19, 2014