The Immune System and Psychiatric Disorders

This study has been completed.
Sponsor:
Collaborator:
St. Olavs Hospital
Information provided by:
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00184418
First received: September 15, 2005
Last updated: October 27, 2009
Last verified: October 2009
  Purpose

The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.


Condition
Stress
Depression
Mania
Personality Disorders
Schizophrenia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Immune System and Psychiatric Disorders

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Biospecimen Retention:   Samples Without DNA

Serum, frozen


Estimated Enrollment: 1400
Study Start Date: January 2005
Estimated Study Completion Date: January 2008
Detailed Description:

Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Adults aged 18 years and above. ADmitted to psychiatric acute ward.

Criteria

Inclusion Criteria:

  • Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria:

  • Patients that do not agree to participate in the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00184418

Locations
Norway
St Olavs Hospital, Department of Psychiatry, Østmarka Hospital
Trondheim, Middle Norway, Norway, N-7040
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Investigators
Study Chair: Solveig K Reitan, MD, PhD St Olavs Hospital/NTNU
  More Information

No publications provided

Responsible Party: Solveig K Reitan, MD, PhD, St. Olavs Hospital HF
ClinicalTrials.gov Identifier: NCT00184418     History of Changes
Other Study ID Numbers: 94463, 11771
Study First Received: September 15, 2005
Last Updated: October 27, 2009
Health Authority: Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:
Immunological
Immune system
Psychiatric
Stress
Psychic trauma
Depression
Mania
Psychoses
Personality disorder
Schizophrenia
Bipolar disorder
Cytokine

Additional relevant MeSH terms:
Mental Disorders
Depression
Depressive Disorder
Personality Disorders
Schizophrenia
Bipolar Disorder
Behavioral Symptoms
Mood Disorders
Schizophrenia and Disorders with Psychotic Features
Affective Disorders, Psychotic

ClinicalTrials.gov processed this record on April 17, 2014