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| Sponsored by: |
National Institute on Aging (NIA) |
| Information provided by: | National Institute on Aging (NIA) |
| ClinicalTrials.gov Identifier: | NCT00182949 |
Purpose
The purpose of this study is to examine the genetic risk factors for aging associated conditions.
| Condition |
|
Aging Cardiovascular Disease |
| Genetics Home Reference related topics: | Heart Diseases Vascular Diseases |
| MedlinePlus related topics: | Heart Diseases Vascular Diseases |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study |
| Official Title: | Genetics and Epidemiology of Aging-Associated Traits in the Sardinian Population (SardiNIA) |
| Estimated Enrollment: | 6000 |
| Study Start Date: | June 2001 |
| Estimated Study Completion Date: | October 2005 |
To simplify the genetic study of risk factors for aging-associated conditions, the Sardinian "founder population" is being used, which has developed to a large modern population over thousands of years without appreciable admixture from without, so that the genetic heterogeneity is relatively reduced. A cohort of 6,000 participants has been enrolled from a cluster of 4 towns. Family history, epidemiological data, and measures of 98 quantitative traits, including cardiovascular risk factors and facets of personality, have been collected. The study is now continuing with longitudinal studies, including second and third visits to repeat measures and add more traits. Full genome scans are being done with the goal of localizing and ultimately identifying genetic variants that account for 5% or more of the variance for each trait.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: National Institute on Aging Protocol Officer | 410-350-3947 | |
| Contact: Participant Recruitment | 011 (39) 0782480078 (Italy) |
| Italy, Sardinia | |||||
| Istituto di Neurogenetica e Neurofarmacologia/Italian National Research (CNR) Lanusei | Recruiting | ||||
| Ogliastra, Sardinia, Italy | |||||
| Contact: Participant Recruitment 011 (39) 0782480078 | |||||
| Principal Investigator: Manuela Uda, MD | |||||
| Principal Investigator: | David Schlessinger, PhD | National Institute on Aging, Laboratory of Genetics |
More Information
| Study ID Numbers: | AG0041 |
| First Received: | September 13, 2005 |
| Last Updated: | July 20, 2007 |
| ClinicalTrials.gov Identifier: | NCT00182949 |
| Health Authority: | United States: Federal Government |
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