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Family Risk Analysis of Substance Use in Attention Deficit Hyperactivity Disorder (ADHD) Youth Treated With Concerta

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Paul Hammerness, MD, Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00181792
First received: September 13, 2005
Last updated: May 2, 2012
Last verified: May 2012
History of Changes
  Purpose

The researchers will study 100 families over three years, each with a child (proband) between the ages of 12-17, with the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnosis of ADHD. The researchers hypothesize smoking will be familial and ADHD probands with a family history of tobacco use will be at increased risk for early initiation and persistence of smoking, compared to ADHD probands with no family history of tobacco use.


Condition Phase
ADHD
Smoking
 Phase 4

Study Type: Observational
Study Design: Observational Model: Family-Based
Official Title: Family Risk Analysis of Substance Use in ADHD Youth Treated With Concerta

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Massachusetts General Hospital:

Enrollment: 70
Study Start Date: May 2005
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Detailed Description:

As Attention Deficit Hyperactivity Disorder (ADHD) is a documented risk factor for smoking in adolescents, and as theoretical considerations suggest that ADHD and tobacco use may share common underlying mechanisms, the proposed study looks to examine the association between smoking and ADHD. Since both ADHD and smoking are known to be familial disorders, one approach to examine the nature of the association between the two disorders is to conduct a familial risk analysis comparing ADHD youth who smoke and ADHD youth who don't smoke. Another approach is to conduct a genetic study, to identify candidate genes associated with nicotine abuse and dependence in ADHD youth and relatives.

This study includes:

  1. assessment of psychopathology and substance use/dependence,
  2. assessment of the family environment, and
  3. assessment of molecular genetics in 100 families with at least one child (proband) between the ages of 12-17 with a DSM-IV diagnosis of ADHD.
  Eligibility

Ages Eligible for Study:   6 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

First-degree relative between the ages of 6-55 years of a family member (proband) between the ages of 12-17 with the DSM-IV diagnosis of ADHD

Criteria

Inclusion Criteria:

  • First-degree relative between the ages of 6-55 years of a family member (proband) between the ages of 12-17 with the DSM-IV diagnosis of ADHD
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00181792

Locations
United States, Massachusetts
Massachusetts General Hospital
Cambridge, Massachusetts, United States, 02138
Sponsors and Collaborators
Massachusetts General Hospital
Investigators
Principal Investigator: Paul Hammerness, MD Massachusetts General Hospital
  More Information

No publications provided

Responsible Party: Paul Hammerness, MD, Assistant Professor Psychiatry, Massachusetts General Hospital
ClinicalTrials.gov Identifier: NCT00181792     History of Changes
Other Study ID Numbers: 2005-P-000278
Study First Received: September 13, 2005
Last Updated: May 2, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Massachusetts General Hospital:
ADHD
smoking
familial risk

Additional relevant MeSH terms:
Smoking
Attention Deficit Disorder with Hyperactivity
Habits
 Attention Deficit and Disruptive Behavior Disorders
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on May 23, 2013