Macrolides to Prevent Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease

This study has been terminated.
(Principal Investigator moved institutions)
Sponsor:
Information provided by (Responsible Party):
Jerry A. Krishnan, Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00181272
First received: September 15, 2005
Last updated: May 9, 2013
Last verified: May 2013
  Purpose

The purpose of this study is to determine whether macrolide therapy is effective in treating patients hospitalized with asthma exacerbations or chronic obstructive pulmonary disease (COPD)exacerbations. We hypothesize that compared to placebo, maintenance therapy with macrolides, when added to usual care, a) improves respiratory symptoms, b) improves quality of life, c) reduces airway inflammation, d) reduces airflow obstruction, and e) decreases the rate of re-exacerbations.


Condition Intervention Phase
Asthma
Chronic Obstructive Pulmonary Disease
Drug: azithromycin
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Macrolides to Prevent Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease

Resource links provided by NLM:


Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • The effect of azithromycin on the rate of exacerbations for asthma or COPD exacerbations after hospital discharge

Secondary Outcome Measures:
  • changes in airflow obstruction (FEV1% predicted)
  • serum biomarkers of airway inflammation (IL-1beta, IL-5, IL-6, IL-8, IL-10, RANTES, IFN-gamma, TNF-alpha, and hs-CRP)
  • respiratory markers of inflammation (EBC measurements - pH)
  • symptom/quality of life measures

Estimated Enrollment: 18
Study Start Date: September 2005
Study Completion Date: July 2006
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Detailed Description:

Asthma and chronic obstructive pulmonary disease (COPD) are the two most common obstructive lung diseases. Chronic airway inflammation and episodic worsening of respiratory symptoms and airflow obstruction (exacerbations) occur in asthma and COPD. Despite major advances in the development of therapies for these respiratory disorders, asthma and COPD exacerbations are common and result in substantial morbidity and mortality. Moreover, patients hospitalized for asthma or COPD exacerbations are at high risk for near fatal and fatal re-exacerbations after discharge home. These observations highlight the need for novel therapies to prevent asthma and COPD exacerbations. The role of macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin) in treating bacterial infections is well established. Recent pre-clinical evidence also suggests that macrolides may posses distinct anti-inflammatory properties and even anti-viral properties. These exciting observations have led to research evaluating the use of maintenance therapy with macrolides in patients with asthma and COPD. Small studies in clinically stable asthma or COPD suggest that maintenance macrolide therapy (e.g., use for 6 weeks), when added to usual care, may attenuate airway inflammation, reduce respiratory symptoms, and improve lung function. However, there are no studies that have evaluated the potential benefits of initiating maintenance macrolide therapy during asthma or COPD exacerbations. We hypothesize that initiating maintenance macrolide therapy in hospitalized patients with asthma or COPD exacerbations will, when added to usual medical care, accelerate the improvement in airflow obstruction, respiratory symptoms, and quality of life and reduce the risk of re-exacerbations after discharge home. The objective of this pilot study is to evaluate the feasibility of the study protocol (recruitment, retention, and adherence to study procedures and medications), as well as collect preliminary data about the proportion of exacerbations due to bacterial or viral infections and estimate potential effect sizes for clinically important outcomes (respiratory symptoms, quality of life, airflow obstruction, airway inflammation, and rate of re-exacerbations). To achieve these objectives, we propose a 48 week randomized, double-blind, placebo-controlled crossover clinical trial (24 weeks azithromycin, 24 weeks placebo) in adults hospitalized for asthma or COPD exacerbations to the Johns Hopkins Hospital or Johns Hopkins Bayview Medical Center.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Physician-diagnosis of asthma, COPD exacerbation, or undifferentiated asthma/COPD exacerbation
  • Admitted to the inpatient medical service at Johns Hopkins Hospital or Johns Hopkins Bayview Medical Center
  • Evidence of airflow obstruction on spirometry (FEV1/FVC<70%)
  • Age 18 years or older

Exclusion Criteria:

  • History of allergy or other contraindication to macrolides (azithromycin, erythromycin, clarithromycin)
  • Treatment with any macrolide in the 4 weeks prior to study entry
  • Elevated AST or ALT (2 or more times the upper limit of normal) on current admission
  • Elevated alkaline phosphatase (>1.25 times the upper limit of normal) on current admission
  • Elevated total serum bilirubin (more than upper limit of normal) on current admission
  • Previous participation in this study
  • Patients prescribed digoxin (azithromycin may increase digoxin levels)
  • Patients prescribed warfarin (azithromycin may increase INR in patients on warfarin)
  • Patients prescribed pimozide (azithromycin may increase risk of arrhythmias)
  • Patient unable to provide consent (e.g., language difficulty or history of dementia)
  • Patient to be discharged to a location other than home (e.g., other hospital, long-term care facility)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00181272

Locations
United States, Maryland
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
Investigators
Principal Investigator: Jerry A Krishnan, MD, PhD Johns Hopkins Medicine
  More Information

No publications provided

Responsible Party: Jerry A. Krishnan, Associate Professor, Johns Hopkins University
ClinicalTrials.gov Identifier: NCT00181272     History of Changes
Other Study ID Numbers: 05-02-17-01
Study First Received: September 15, 2005
Last Updated: May 9, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Johns Hopkins University:
chronic obstructive pulmonary disease (COPD)
undifferentiated asthma/COPD

Additional relevant MeSH terms:
Asthma
Lung Diseases
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Bronchial Diseases
Respiratory Tract Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Azithromycin
Anti-Bacterial Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on August 21, 2014