HLA Matching - Unrelated Umbilical Cord Blood Transplantation

This study has been completed.
Sponsor:
Information provided by:
Ann & Robert H Lurie Children's Hospital of Chicago
ClinicalTrials.gov Identifier:
NCT00179946
First received: September 12, 2005
Last updated: January 14, 2008
Last verified: January 2008
  Purpose

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.


Condition Intervention
Hematologic Diseases
Procedure: HLA typing

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Resource links provided by NLM:


Further study details as provided by Ann & Robert H Lurie Children's Hospital of Chicago:

Estimated Enrollment: 30
Study Start Date: June 2003
Study Completion Date: April 2006
Primary Completion Date: April 2006 (Final data collection date for primary outcome measure)
Detailed Description:

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

  1. Is HLA matching beneficial to unrelated UCB transplantation?
  2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
  3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
  4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

  • Refusal to participate in study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00179946

Locations
United States, Illinois
Children's Memorial Hospital
Chicago, Illinois, United States, 60622
Sponsors and Collaborators
Ann & Robert H Lurie Children's Hospital of Chicago
Investigators
Principal Investigator: Susanna Rodriguez-Marino, M.D. Ann & Robert H Lurie Children's Hospital of Chicago
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00179946     History of Changes
Other Study ID Numbers: BMT 0603 HLA
Study First Received: September 12, 2005
Last Updated: January 14, 2008
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Hematologic Diseases

ClinicalTrials.gov processed this record on August 19, 2014