Biomagnetic Signals of Intestinal Ischemia II (SQUID)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Vanderbilt University.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Information provided by:
Vanderbilt University
ClinicalTrials.gov Identifier:
NCT00179036
First received: September 13, 2005
Last updated: June 24, 2011
Last verified: June 2011
  Purpose

The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.


Condition Phase
Ischemia
Phase 1

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Biomagnetic Signals of Intestinal Ischemia II

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • To observe a difference in the magnetic activity between the normal and diseased smooth muscle of the small intestine [ Time Frame: 2010 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Create mathematical and computer models of electrical activity of smooth muscle [ Time Frame: 2010 ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: January 2000
Estimated Study Completion Date: June 2012
Groups/Cohorts
Good blood flow
Group without any ischemia to the small intestine
Poor blood flow
Group with partial ischemia to the small intestine

Detailed Description:

The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

primary care clinic

Criteria

Inclusion Criteria:

  • Normal subjects and those with diagnosed mesenteric ischemia

Exclusion Criteria:

  • Subjects who report a tendency toward claustrophobia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00179036

Contacts
Contact: Alan Bradshaw, PhD 615-322-0705 alan.bradshaw@vanderbilt.edu

Locations
United States, Tennessee
Vanderbilt University Medical Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Joan Kaiser, RN    615-343-5821    joan.kaiser@vanderbilt.edu   
Principal Investigator: William O Richards, MD         
Sponsors and Collaborators
Vanderbilt University
Investigators
Principal Investigator: William O. Richards, MD Vanderbilt University
  More Information

No publications provided

Responsible Party: Dr. William O. Richards, Vanderbilt University
ClinicalTrials.gov Identifier: NCT00179036     History of Changes
Other Study ID Numbers: 060426, NIH RO1 DK 58197-05
Study First Received: September 13, 2005
Last Updated: June 24, 2011
Health Authority: United States: Federal Government

Keywords provided by Vanderbilt University:
Blood supply
Mesentery

Additional relevant MeSH terms:
Ischemia
Pathologic Processes

ClinicalTrials.gov processed this record on September 16, 2014