Change in Thrombin Generation Potential and Thromboelastography During the Menstrual Cycle
The primary objective of this study is to describe characteristics and trends for thrombin generation (TG) and thromboelastography (TEG) at 4 time points during the menstrual cycle.
Von Willebrand Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Changes in Thrombin Generation Potential and Thromboelastography During the Menstrual Cycle|
- Endogenous Thrombin Potential [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]Comparison of 4 values collected during 4 phases of through the menstrual cycle
|Study Start Date:||September 2005|
|Study Completion Date:||April 2013|
|Primary Completion Date:||April 2013 (Final data collection date for primary outcome measure)|
We propose that TG and TEG will be more sensitive than traditional coagulation assays to detect physiologic variation in hemostasis, fibrinolysis, and platelet activation throughout the menstrual cycle. We expect that TG and TEG will better discriminate patients with vWD than traditional coagulation studies during the menstrual cycle. In this study we plan to measure TG and TEG in healthy women and women with von Willebrand's disorder during four phases of the menstrual cycle. We will compare specific measurements of endogenous thrombin generation potential from the TG and fibrinolysis and platelet activation from the TEG with standard measures of coagulation, fibrinolysis, and platelet activation markers during the menstrual cycle.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00178542
|United States, Texas|
|The University of Texas Health Science Center at Houston|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Deborah Brown, MD||The University of Texas Health Science Center, Houston|