Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury - Full Text View

Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

This study is currently recruiting participants.
Verified by University of Rochester, September 2006

Sponsored by:	University of Rochester
Information provided by:	University of Rochester
ClinicalTrials.gov Identifier:	NCT00178295

Purpose

Treatment for brain cancer may include radiation therapy. Radiation therapy is the treatment of tumors with X-rays. This study is related to understanding the side effects of radiation treatment for brain tumors.

This study is being conducted by the University of Rochester Cancer Center to compare the extent of side effects of brain cancer treatment with changes in levels of blood proteins called cytokines.

Condition	Intervention
Brain Neoplasm	Procedure: Radiation Therapy

MedlinePlus related topics:

Brain Cancer Cancer Childhood Brain Tumors

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study

Official Title:	Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Any patient who will be treated to the brain or spinal axis for a CNS tum Patients so treated will be stratified according to whether or not the hypo is included in the treatment fields.
Patients receiving external beam radiation to the brain may also be rece chemotherapy or interferon-beta. (Add. #1, 11-9-95)
Patients receiving high dose rate (stereotactic radiosurgery) are eligible.
Patients must sign a study specific informed consent meeting all federal a guidelines.
Patients of any age, including children, are eligible (Add. #3, 11/25/97).

Exclusion Criteria:

Patients who have a malignancy involving the hypothalamic-pituitary ax
Patients who are not treated with irradiation to the brain or spinal axis.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00178295

Contacts


Contact: Louis S Constine, MD	585-275-5622

Locations


United States, New York
	University of Rochester, Dept. Radiation Oncology	Recruiting
	Rochester, New York, United States, 14642
	Contact: Louis Constine, MD
	Principal Investigator: Louis Constine, MD

Sponsors and Collaborators

University of Rochester

Investigators


Study Chair:	Louis S Constine, MD	Universtiy of Rochester, Dept of Radiation Oncology

Study Chair:	Ralph Brasacchio, MD	University of Rochester, Department of Radiation Oncology

Study Chair:	Paul Okunieff, MD	University of Rochester, Department of Radiation Oncology

More Information

Study ID Numbers:	URCC 11095
First Received:	September 12, 2005
Last Updated:	September 6, 2006
ClinicalTrials.gov Identifier:	NCT00178295
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Brain Neoplasms

Wounds and Injuries

Disorders of Environmental Origin

Central Nervous System Diseases

Central Nervous System Neoplasms

Trauma, Nervous System

Brain Diseases

Nervous System Neoplasms

Additional relevant MeSH terms:

Neoplasms

Neoplasms by Site

Nervous System Diseases

ClinicalTrials.gov processed this record on September 05, 2008