Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

This study is currently recruiting participants.

Verified by University of Rochester, May 2009

First Received: September 12, 2005 Last Updated: May 15, 2009 History of Changes

Sponsored by:	University of Rochester
Information provided by:	University of Rochester
ClinicalTrials.gov Identifier:	NCT00178295

Purpose

Treatment for brain cancer may include radiation therapy. Radiation therapy is the treatment of tumors with X-rays. This study is related to understanding the side effects of radiation treatment for brain tumors.

This study is being conducted by the University of Rochester Cancer Center to compare the extent of side effects of brain cancer treatment with changes in levels of blood proteins called cytokines.

Condition	Intervention
Brain Neoplasm	Radiation: Radiation Therapy

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

Resource links provided by NLM:

MedlinePlus related topics: Brain Cancer Cancer Childhood Brain Tumors Radiation Therapy

U.S. FDA Resources

Further study details as provided by University of Rochester:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

Blood plasma

Estimated Enrollment:	80
Study Start Date:	November 1999

Intervention Details:

standard of care for the cancer being treated

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patient who are going to receive radiation therapy as part of the treatment for their brain cancer

Criteria

Inclusion Criteria:

Any patient who will be treated to the brain or spinal axis for a CNS tum Patients so treated will be stratified according to whether or not the hypo is included in the treatment fields.
Patients receiving external beam radiation to the brain may also be rece chemotherapy or interferon-beta. (Add. #1, 11-9-95)
Patients receiving high dose rate (stereotactic radiosurgery) are eligible.
Patients must sign a study specific informed consent meeting all federal a guidelines.
Patients of any age, including children, are eligible (Add. #3, 11/25/97).

Exclusion Criteria:

Patients who have a malignancy involving the hypothalamic-pituitary ax
Patients who are not treated with irradiation to the brain or spinal axis.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00178295

Contacts

Contact: Louis S Constine, MD

585-275-5622

Locations

United States, New York
University of Rochester, Dept. Radiation Oncology	Recruiting
Rochester, New York, United States, 14642
Contact: Louis Constine, MD
Principal Investigator: Louis Constine, MD

Sponsors and Collaborators

University of Rochester

Investigators

Study Chair:	Louis S Constine, MD	Universtiy of Rochester, Dept of Radiation Oncology
Study Chair:	Ralph Brasacchio, MD	University of Rochester, Department of Radiation Oncology
Study Chair:	Paul Okunieff, MD	University of Rochester, Department of Radiation Oncology

More Information

No publications provided

Responsible Party:	University of Rochester, Medical Center ( Louis Constine, Md )
Study ID Numbers:	URCC 11095
Study First Received:	September 12, 2005
Last Updated:	May 15, 2009
ClinicalTrials.gov Identifier:	NCT00178295 History of Changes
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Brain Neoplasms
Wounds and Injuries
Disorders of Environmental Origin
Central Nervous System Diseases

Central Nervous System Neoplasms
Trauma, Nervous System
Brain Diseases
Nervous System Neoplasms

Additional relevant MeSH terms:

Brain Neoplasms
Neoplasms
Neoplasms by Site
Nervous System Diseases
Wounds and Injuries
Disorders of Environmental Origin

Central Nervous System Diseases
Central Nervous System Neoplasms
Trauma, Nervous System
Brain Diseases
Nervous System Neoplasms

ClinicalTrials.gov processed this record on July 06, 2009