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Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care Unit
This study is currently recruiting participants.
Verified by University of Pittsburgh, December 2009
First Received: September 13, 2005   Last Updated: December 2, 2009   History of Changes
Sponsor: University of Pittsburgh
Collaborator: Abraxis BioScience Inc.
Information provided by: University of Pittsburgh
ClinicalTrials.gov Identifier: NCT00177814
  Purpose

The proposed endpoints of the study would be: comparative use of piperacillin versus broader spectrum agents (e.g., piperacillin/tazobactam, etc.) [measured as defined daily doses per 1000 patient days]; physician acceptance of piperacillin as part of a streamlining program [measured as successful occurrences of the use of piperacillin as streamlining therapy]; changes in susceptibility patterns of broad spectrum antibiotics [measured as % Gram negative bacilli susceptible to each of the commonly used broad spectrum antibiotics]; and outcome of patients treated with streamlined therapy.


Condition
Gram-Negative Bacterial Infections

Study Type: Observational
Study Design: Retrospective
Official Title: Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care Unit

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 1000
Study Start Date: September 2005
Estimated Study Completion Date: December 2012
Detailed Description:

The following variables will be followed: time and location of positive cultures, underlying diseases and severity of illness, recent immunomodulative therapies, physical exam findings, laboratory and radiographical data, antimicrobial usage, microbiological data and resistance patterns, choice of antibiotics once organism is identified, suspected source of infection, bacteriological outcomes, laboratory results, demographic information, medications, clinical outcome, gender, height, weight, ethnicity, and past medical history.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients treated with piperacillin/tazobactam and or piperacillin

Criteria

Inclusion Criteria:

  • Patients with Gram negative infections treated with piperacillin/tazobactam and/or piperacillin
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00177814

Contacts
Contact: David Paterson, MD 412-648-6401 patersond@dom.pitt.edu
Contact: Diana Pakstis, RN, BSN 412-648-6401 pakstisdl@dom.pitt.edu

Locations
United States, Pennsylvania
University of Pittsburgh Medical Center Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: David Paterson, MD     412-648-6401     patersond@dom.pitt.edu    
Contact: Diana Pakstis, RN, BSN     412-648-6401     pakstisdl@dom.pitt.edu    
Principal Investigator: David Paterson, MD            
Sponsors and Collaborators
University of Pittsburgh
Abraxis BioScience Inc.
Investigators
Principal Investigator: David Paterson, MD University of Pittsburgh
  More Information

No publications provided

Responsible Party: UPMC ( David Paterson, MD )
Study ID Numbers: IRB # 0508074
Study First Received: September 13, 2005
Last Updated: December 2, 2009
ClinicalTrials.gov Identifier: NCT00177814     History of Changes
Health Authority: United States: Institutional Review Board

Keywords provided by University of Pittsburgh:
pipercillin
gram negative bacteria infections

Additional relevant MeSH terms:
Bacterial Infections
Anti-Infective Agents
Anti-Bacterial Agents
Therapeutic Uses
Piperacillin
Infection
Pharmacologic Actions
Gram-Negative Bacterial Infections

ClinicalTrials.gov processed this record on February 08, 2010