Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice
The purpose of this study is to determine if immunophilin ligands may have the potential to reverse hair loss.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Neurotrophic Effects of Immunophilin Ligands on Human Hair Follicles Grafted Onto Service Combined Immunodeficient (SCID) Mice|
- The average number of terminal hairs per graft will be compared between the control and the treated group.
- The number of follicles in anagen, catagen and telogen per graft will be averaged for each group. The results will be compared between the control and the treated groups.
|Study Start Date:||July 2003|
|Estimated Study Completion Date:||September 2004|
Preliminary experiments in C57BL/6J mice showed that immunophilin ligand FK506 and its non-immunosuppressive analogs, GP11046 and GP11511 were capable of promoting telogen to anagen transition. Since GP11046 and GP11511 possess the neurotrophic properties of FK506 without its immunosuppressant capability, the neural action of these immunophilin ligands may play an important role in the hair cycle. This finding has significant clinical implications in that immunophilin ligands may have the potential to reverse alopecia. To further investigate this possibility we propose to explore the response of transplanted miniaturized scalp hair follicles to topically applied immunophilin ligands.
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Marna Ericson, Ph D||University of Minnesota - Clinical and Translational Science Institute|
|Principal Investigator:||Maria Hordinsky, MD||University of Minnesota - Clinical and Translational Science Institute|